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- W2086718822 abstract "Significance Thyroid cancer is common and has an excellent outcome in many cases, although a proportion of these tumors have a progressive clinical course and high mortality. Using whole-transcriptome (RNA-sequencing) analysis, we discovered previously unknown genetic events, anaplastic lymphoma kinase ( ALK ) gene fusions, in thyroid cancer and demonstrate that they occur more often in aggressive cancers. The most common fusion identified in these tumors involved the striatin ( STRN ) gene, and we show that it is transforming and tumorigenic in vivo. Finally, we demonstrate that the kinase activity of STRN-ALK can be blocked by ALK inhibitors, raising a possibility that ALK fusions may be used as a therapeutic target for patients with the most aggressive and frequently lethal forms of thyroid cancer." @default.
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- W2086718822 date "2014-02-03" @default.
- W2086718822 modified "2023-10-11" @default.
- W2086718822 title "Identification of the transforming <i>STRN-ALK</i> fusion as a potential therapeutic target in the aggressive forms of thyroid cancer" @default.
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- W2086718822 doi "https://doi.org/10.1073/pnas.1321937111" @default.
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