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- W2086719581 abstract "Drug therapy of LCO in the newborn has developed empirically with few cardiovascular (CV) studies. The effectiveness of Db at various dosages was evaluated in the treatment of 10 infants with LCO, 8 of which had failed to respond to prior treatment with cardiotonic drugs. Patients were 9 hrs to 7 wks old and diagnoses included infection (5), CV defects (4), and hemorrhage (1). Except for brief periods at higher dosages, Db was infused in dosages from 2-12 μg/kg/min for 7-123 hrs. Infusions of other pressors remained constant initially. If the patient responded favorably to Db, the other cardiotonic agent was discontinued. Improvement was noted in decreased skin perfusion (100%), elevated atrial pressure (80%), metabolic acidosis (75%), oliguria (67%), arterial hypotension (67%) and tachycardia (60%). Four patients died including 3 with structural CV defects and 1 with hemorrhage. Tachycardia of 15-20 beats/min occurred in 3 patients at dosages above 12 μg/kg/min. No arrhythmias were induced or increased by Db. Db appears to be effective for treating LCO in infants, primarily by increasing contractility and peripheral vasodilatation. Dosages should be limited to 2-12 μg/kg/min." @default.
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- W2086719581 date "1981-04-01" @default.
- W2086719581 modified "2023-10-18" @default.
- W2086719581 title "1458 RESPONSE OF INFANTS WITH LOW CARDIAC OUTPUT (LCO) TO DOBUTAMINE (Db)" @default.
- W2086719581 doi "https://doi.org/10.1203/00006450-198104001-01487" @default.
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