Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086736698> ?p ?o ?g. }
- W2086736698 endingPage "311" @default.
- W2086736698 startingPage "305" @default.
- W2086736698 abstract "The present study evaluated the effects of ibudilast on impaired passive avoidance responses and hippocampal long-term potentiation (LTP) caused by transient cerebral ischemia in rats. The hippocampal nerve cell density was also measured. The latency determined in retention trials of passive avoidance shortened significantly in the 4-vessel occlusion (4VO) group (in which four blood vessels were occluded for 20 min to cause cerebral ischemia). A significant recovery in the latency was observed by administration of ibudilast (10 mg kg (-1)). The population spike amplitude in both the hippocampal CA1 region and perforant path-dentate gyrus synapses was potentiated by tetanus stimulation in the sham-operated group, while in the 4VO group, LTP was significantly inhibited. This inhibition was reversed by administration of ibudilast (10 mg kg (-1)). A marked reduction of cell densities in the CA1 region was observed in the 4VO group compared with the normal group. The nerve cell density in the hippocampal CA1 region was decreased by 20 min of cerebral ischemia. Ibudilast significantly inhibited the reduction of cell densities in a dose-dependent manner. In contrast, the cell density in the dentate gyrus was comparable in the 4VO and normal groups, and no significant changes were observed in the ibudilast groups. These findings suggest that ibudilast might possess neuronally protective properties, i.e. protecting neurons not only from deaths but also from functional damage due to certain cerebral ischemia." @default.
- W2086736698 created "2016-06-24" @default.
- W2086736698 creator A5004690924 @default.
- W2086736698 creator A5046115754 @default.
- W2086736698 creator A5047019247 @default.
- W2086736698 creator A5047706387 @default.
- W2086736698 creator A5055518358 @default.
- W2086736698 creator A5059868098 @default.
- W2086736698 creator A5061044019 @default.
- W2086736698 date "2002-04-01" @default.
- W2086736698 modified "2023-09-25" @default.
- W2086736698 title "Effects of ibudilast on hippocampal long-term potentiation and passive avoidance responses in rats with transient cerebral ischemia" @default.
- W2086736698 cites W1970546051 @default.
- W2086736698 cites W1976140941 @default.
- W2086736698 cites W1980723823 @default.
- W2086736698 cites W1988746120 @default.
- W2086736698 cites W1994864596 @default.
- W2086736698 cites W1997369155 @default.
- W2086736698 cites W2001266454 @default.
- W2086736698 cites W2009782005 @default.
- W2086736698 cites W2011104595 @default.
- W2086736698 cites W2011634586 @default.
- W2086736698 cites W2013789920 @default.
- W2086736698 cites W2013833441 @default.
- W2086736698 cites W2019049115 @default.
- W2086736698 cites W2020108526 @default.
- W2086736698 cites W2020622209 @default.
- W2086736698 cites W2022557473 @default.
- W2086736698 cites W2024027789 @default.
- W2086736698 cites W2028049923 @default.
- W2086736698 cites W2039904611 @default.
- W2086736698 cites W2041459295 @default.
- W2086736698 cites W2049511526 @default.
- W2086736698 cites W2055692276 @default.
- W2086736698 cites W2058945055 @default.
- W2086736698 cites W2059033057 @default.
- W2086736698 cites W2061234219 @default.
- W2086736698 cites W2061909092 @default.
- W2086736698 cites W2075642592 @default.
- W2086736698 cites W2076009972 @default.
- W2086736698 cites W2085106588 @default.
- W2086736698 cites W2089981038 @default.
- W2086736698 cites W2092912030 @default.
- W2086736698 cites W2093245837 @default.
- W2086736698 cites W2106673320 @default.
- W2086736698 cites W2117594247 @default.
- W2086736698 cites W2135389931 @default.
- W2086736698 cites W2171762244 @default.
- W2086736698 doi "https://doi.org/10.1006/phrs.2002.0949" @default.
- W2086736698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12030794" @default.
- W2086736698 hasPublicationYear "2002" @default.
- W2086736698 type Work @default.
- W2086736698 sameAs 2086736698 @default.
- W2086736698 citedByCount "16" @default.
- W2086736698 countsByYear W20867366982012 @default.
- W2086736698 countsByYear W20867366982014 @default.
- W2086736698 countsByYear W20867366982015 @default.
- W2086736698 countsByYear W20867366982017 @default.
- W2086736698 countsByYear W20867366982022 @default.
- W2086736698 crossrefType "journal-article" @default.
- W2086736698 hasAuthorship W2086736698A5004690924 @default.
- W2086736698 hasAuthorship W2086736698A5046115754 @default.
- W2086736698 hasAuthorship W2086736698A5047019247 @default.
- W2086736698 hasAuthorship W2086736698A5047706387 @default.
- W2086736698 hasAuthorship W2086736698A5055518358 @default.
- W2086736698 hasAuthorship W2086736698A5059868098 @default.
- W2086736698 hasAuthorship W2086736698A5061044019 @default.
- W2086736698 hasConcept C126322002 @default.
- W2086736698 hasConcept C148762608 @default.
- W2086736698 hasConcept C170493617 @default.
- W2086736698 hasConcept C25274449 @default.
- W2086736698 hasConcept C2776464000 @default.
- W2086736698 hasConcept C2779277159 @default.
- W2086736698 hasConcept C42219234 @default.
- W2086736698 hasConcept C541997718 @default.
- W2086736698 hasConcept C71924100 @default.
- W2086736698 hasConcept C98274493 @default.
- W2086736698 hasConceptScore W2086736698C126322002 @default.
- W2086736698 hasConceptScore W2086736698C148762608 @default.
- W2086736698 hasConceptScore W2086736698C170493617 @default.
- W2086736698 hasConceptScore W2086736698C25274449 @default.
- W2086736698 hasConceptScore W2086736698C2776464000 @default.
- W2086736698 hasConceptScore W2086736698C2779277159 @default.
- W2086736698 hasConceptScore W2086736698C42219234 @default.
- W2086736698 hasConceptScore W2086736698C541997718 @default.
- W2086736698 hasConceptScore W2086736698C71924100 @default.
- W2086736698 hasConceptScore W2086736698C98274493 @default.
- W2086736698 hasIssue "4" @default.
- W2086736698 hasLocation W20867366981 @default.
- W2086736698 hasLocation W20867366982 @default.
- W2086736698 hasOpenAccess W2086736698 @default.
- W2086736698 hasPrimaryLocation W20867366981 @default.
- W2086736698 hasRelatedWork W1967944001 @default.
- W2086736698 hasRelatedWork W2063055145 @default.
- W2086736698 hasRelatedWork W2077276022 @default.
- W2086736698 hasRelatedWork W2093448654 @default.
- W2086736698 hasRelatedWork W2365277294 @default.
- W2086736698 hasRelatedWork W2365626381 @default.