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- W2086737981 abstract "Summary Lymphoid cells from genetically-susceptible BALB/c mice immunized against a glycoconjugate of the protozoan parasite, Leishmania major, promote chronic cutaneous disease in BALB/c nude mice. This cell population therefore differs from cells harvested from non-immunized BALB/c mice that are known to be potent mediators of protection against cutaneous leishmaniasis in minimally-reconstituted, syngeneic nude mice. The glycoconjugate when injected into genetically-resistant C57BL/6 mice will increase the size and persistence of cutaneous lesions. Recent studies have established that the water soluble glycoconjugate is derived from a membrane-bound glycolipid that is a receptor used by the parasite in the attachment to macrophages. This glycolipid can protectively immunize mice against cutaneous leishmaniasis. Identification of a vaccinating glycolipid antigen and a suppressogenic component derived from it will greatly facilitate analysis of disease-promoting and resistance-promoting immunity in cutaneous leishmaniasis. However, the fact that a host-protective antigen contains a disease-promoting component may militate against the immediate use of this molecular vaccine in man." @default.
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- W2086737981 date "1986-05-01" @default.
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- W2086737981 title "The glycoconjugate derived from a Leishmania major receptor for macrophages is a suppressogenic, disease-promoting antigen in murine cutaneous leishmaniasis" @default.
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- W2086737981 doi "https://doi.org/10.1111/j.1365-3024.1986.tb01037.x" @default.
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