FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086740777> ?p ?o ?g. }

• W2086740777 endingPage "15269" @default.
• W2086740777 startingPage "15269" @default.
• W2086740777 abstract "Hepatocellular carcinoma is one of the most common cancers worldwide, and a leading cause of cancer-related death. Owing to unsatisfactory clinical outcomes under the current standard of care, there is a need to search for and identify novel and potent therapeutic targets to improve patient outcomes. Sorafenib is the first and only approved targeted therapy for the treatment of hepatocellular carcinoma. Besides functioning as a multiple tyrosine kinase, sorafenib also acts via a kinase-independent mechanism to target signal transducer and activator of transcription 3 (STAT3) signaling in hepatocellular carcinoma cells. STAT3 is a key regulator of inflammation, cell survival, and tumorigenesis of liver cells, and the high percentage of hepatocellular carcinoma cells with constitutively active STAT3 justifies targeting it for the development of novel therapeutics. Sorafenib inactivates STAT3 and STAT3-related signaling by inducing a conformational change in and releasing the autoinhibition of Src homology region 2 domain-containing phosphatase-1. This phosphatase negatively regulates STAT3 activity, which leads to the subsequent apoptosis of cancer cells. The novel anti-cancer property of sorafenib will be discussed in this review, not only adding information regarding its mechanism of action but also providing an innovative approach for the development of cancer therapeutics in the future." @default.
• W2086740777 created "2016-06-24" @default.
• W2086740777 creator A5039644586 @default.
• W2086740777 creator A5050305483 @default.
• W2086740777 creator A5067462259 @default.
• W2086740777 creator A5085573537 @default.
• W2086740777 date "2014-01-01" @default.
• W2086740777 modified "2023-09-23" @default.
• W2086740777 title "Downregulation of signal transducer and activator of transcription 3 by sorafenib: A novel mechanism for hepatocellular carcinoma therapy" @default.
• W2086740777 cites W1550156431 @default.
• W2086740777 cites W1605768520 @default.
• W2086740777 cites W1967447165 @default.
• W2086740777 cites W1970409885 @default.
• W2086740777 cites W1971837077 @default.
• W2086740777 cites W1975464455 @default.
• W2086740777 cites W1981989535 @default.
• W2086740777 cites W1982164530 @default.
• W2086740777 cites W1986060457 @default.
• W2086740777 cites W1986625462 @default.
• W2086740777 cites W1990738958 @default.
• W2086740777 cites W1994193851 @default.
• W2086740777 cites W1995997868 @default.
• W2086740777 cites W1999468766 @default.
• W2086740777 cites W2005714383 @default.
• W2086740777 cites W2017792524 @default.
• W2086740777 cites W2024282024 @default.
• W2086740777 cites W2029275361 @default.
• W2086740777 cites W2032674547 @default.
• W2086740777 cites W2036564735 @default.
• W2086740777 cites W2039845199 @default.
• W2086740777 cites W2044764720 @default.
• W2086740777 cites W2045429389 @default.
• W2086740777 cites W2051684210 @default.
• W2086740777 cites W2052550764 @default.
• W2086740777 cites W2052656103 @default.
• W2086740777 cites W2054371348 @default.
• W2086740777 cites W2062005942 @default.
• W2086740777 cites W2068542139 @default.
• W2086740777 cites W2070166036 @default.
• W2086740777 cites W2070396671 @default.
• W2086740777 cites W2072669480 @default.
• W2086740777 cites W2073125132 @default.
• W2086740777 cites W2086307485 @default.
• W2086740777 cites W2096556320 @default.
• W2086740777 cites W2114994872 @default.
• W2086740777 cites W2115744231 @default.
• W2086740777 cites W2117962285 @default.
• W2086740777 cites W2118310862 @default.
• W2086740777 cites W2119242310 @default.
• W2086740777 cites W2123546830 @default.
• W2086740777 cites W2126159152 @default.
• W2086740777 cites W2132992001 @default.
• W2086740777 cites W2137135537 @default.
• W2086740777 cites W2137649343 @default.
• W2086740777 cites W2137813001 @default.
• W2086740777 cites W2140765540 @default.
• W2086740777 cites W2140786721 @default.
• W2086740777 cites W2159730182 @default.
• W2086740777 cites W2163403599 @default.
• W2086740777 cites W2163776261 @default.
• W2086740777 cites W2167210859 @default.
• W2086740777 cites W2412659346 @default.
• W2086740777 cites W4211105405 @default.
• W2086740777 cites W4245403358 @default.
• W2086740777 doi "https://doi.org/10.3748/wjg.v20.i41.15269" @default.
• W2086740777 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4223260" @default.
• W2086740777 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25386075" @default.
• W2086740777 hasPublicationYear "2014" @default.
• W2086740777 type Work @default.
• W2086740777 sameAs 2086740777 @default.
• W2086740777 citedByCount "25" @default.
• W2086740777 countsByYear W20867407772015 @default.
• W2086740777 countsByYear W20867407772016 @default.
• W2086740777 countsByYear W20867407772017 @default.
• W2086740777 countsByYear W20867407772018 @default.
• W2086740777 countsByYear W20867407772019 @default.
• W2086740777 countsByYear W20867407772020 @default.
• W2086740777 countsByYear W20867407772021 @default.
• W2086740777 countsByYear W20867407772022 @default.
• W2086740777 countsByYear W20867407772023 @default.
• W2086740777 crossrefType "journal-article" @default.
• W2086740777 hasAuthorship W2086740777A5039644586 @default.
• W2086740777 hasAuthorship W2086740777A5050305483 @default.
• W2086740777 hasAuthorship W2086740777A5067462259 @default.
• W2086740777 hasAuthorship W2086740777A5085573537 @default.
• W2086740777 hasBestOaLocation W20867407771 @default.
• W2086740777 hasConcept C104317684 @default.
• W2086740777 hasConcept C121608353 @default.
• W2086740777 hasConcept C126322002 @default.
• W2086740777 hasConcept C127561419 @default.
• W2086740777 hasConcept C171958077 @default.
• W2086740777 hasConcept C2776231280 @default.
• W2086740777 hasConcept C2778019345 @default.
• W2086740777 hasConcept C2778695046 @default.
• W2086740777 hasConcept C2778923194 @default.
• W2086740777 hasConcept C2781230642 @default.
• W2086740777 hasConcept C502942594 @default.
• W2086740777 hasConcept C55493867 @default.

• next