FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086749348> ?p ?o ?g. }

• W2086749348 endingPage "233" @default.
• W2086749348 startingPage "228" @default.
• W2086749348 abstract "BACKGROUND--Platelet activating factor (PAF) has been implicated in the pathogenesis of airway hyperresponsiveness in asthma. The purpose of this study was to evaluate the effects of a selective PAF antagonist (WEB 2086), given in doses known to antagonise the effects of inhaled PAF in human subjects, on allergen induced early and late asthmatic responses and on airway hyperresponsiveness. METHODS--Eight atopic, mildly asthmatic subjects were studied during a screening period and two treatment periods. During the screening period subjects inhaled an allergen to which they were known to be sensitised and the response was measured as the fall in the forced expired volume in one second (FEV1) to show the presence of early (0-1 h) and late (3-7 h) asthmatic responses. On another day the subjects inhaled allergen diluent. During the treatment periods subjects inhaled allergen after one week9s pretreatment with WEB 2086 (100 mg three times a day) or placebo administered in a randomised, double blind, crossover fashion. Histamine airway responsiveness was measured 24 hours before and 24 hours after allergen and the results were expressed as the provocative concentration causing a 20% fall in FEV1 (PC20). RESULTS--The maximal early asthmatic response after allergen with placebo treatment was 18.4% (SE 4.4%) and with WEB 2086 18.9% (4.4%). The maximal late response with placebo treatment was 21.7% (5.3%) and with WEB 2086 21.2% (3.0%). The log difference (before and after allergen) in histamine PC20 was 0.35 (0.06) after placebo treatment and 0.30 (0.1) after WEB 2086. CONCLUSIONS--These results indicate that one week of treatment with an orally administered PAF antagonist (WEB 2086) does not attenuate allergen induced early or late responses or airway hyperresponsiveness." @default.
• W2086749348 created "2016-06-24" @default.
• W2086749348 creator A5063319935 @default.
• W2086749348 creator A5070180955 @default.
• W2086749348 date "1989-09-01" @default.
• W2086749348 modified "2023-10-18" @default.
• W2086749348 title "Relation between leisure time exercise and cardiovascular risk factors among 15-year-olds in eastern Finland." @default.
• W2086749348 cites W1582016451 @default.
• W2086749348 cites W1974307247 @default.
• W2086749348 cites W1977905001 @default.
• W2086749348 cites W1991182643 @default.
• W2086749348 cites W1992982936 @default.
• W2086749348 cites W2000016741 @default.
• W2086749348 cites W2005542472 @default.
• W2086749348 cites W2011818646 @default.
• W2086749348 cites W2016343960 @default.
• W2086749348 cites W2024223829 @default.
• W2086749348 cites W2033513259 @default.
• W2086749348 cites W2035901129 @default.
• W2086749348 cites W2038243655 @default.
• W2086749348 cites W2038780234 @default.
• W2086749348 cites W2055496920 @default.
• W2086749348 cites W2056787580 @default.
• W2086749348 cites W2063019951 @default.
• W2086749348 cites W2073506513 @default.
• W2086749348 cites W2081202903 @default.
• W2086749348 cites W2082609744 @default.
• W2086749348 cites W2102317852 @default.
• W2086749348 cites W2107932835 @default.
• W2086749348 cites W2114178639 @default.
• W2086749348 cites W2125846325 @default.
• W2086749348 cites W2129551771 @default.
• W2086749348 cites W2135367468 @default.
• W2086749348 cites W2143420792 @default.
• W2086749348 cites W2145539303 @default.
• W2086749348 cites W2165334435 @default.
• W2086749348 cites W2170591342 @default.
• W2086749348 cites W2279710334 @default.
• W2086749348 cites W2410183519 @default.
• W2086749348 cites W2419577808 @default.
• W2086749348 cites W312211203 @default.
• W2086749348 cites W81219586 @default.
• W2086749348 doi "https://doi.org/10.1136/jech.43.3.228" @default.
• W2086749348 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1052841" @default.
• W2086749348 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2607300" @default.
• W2086749348 hasPublicationYear "1989" @default.
• W2086749348 type Work @default.
• W2086749348 sameAs 2086749348 @default.
• W2086749348 citedByCount "45" @default.
• W2086749348 countsByYear W20867493482012 @default.
• W2086749348 countsByYear W20867493482014 @default.
• W2086749348 countsByYear W20867493482015 @default.
• W2086749348 countsByYear W20867493482016 @default.
• W2086749348 countsByYear W20867493482019 @default.
• W2086749348 crossrefType "journal-article" @default.
• W2086749348 hasAuthorship W2086749348A5063319935 @default.
• W2086749348 hasAuthorship W2086749348A5070180955 @default.
• W2086749348 hasBestOaLocation W20867493481 @default.
• W2086749348 hasConcept C1122143 @default.
• W2086749348 hasConcept C126322002 @default.
• W2086749348 hasConcept C142724271 @default.
• W2086749348 hasConcept C203014093 @default.
• W2086749348 hasConcept C204787440 @default.
• W2086749348 hasConcept C207480886 @default.
• W2086749348 hasConcept C27081682 @default.
• W2086749348 hasConcept C2776042228 @default.
• W2086749348 hasConcept C2776178081 @default.
• W2086749348 hasConcept C2776238763 @default.
• W2086749348 hasConcept C2776954882 @default.
• W2086749348 hasConcept C2777714996 @default.
• W2086749348 hasConcept C2780510475 @default.
• W2086749348 hasConcept C42219234 @default.
• W2086749348 hasConcept C71924100 @default.
• W2086749348 hasConcept C87813604 @default.
• W2086749348 hasConceptScore W2086749348C1122143 @default.
• W2086749348 hasConceptScore W2086749348C126322002 @default.
• W2086749348 hasConceptScore W2086749348C142724271 @default.
• W2086749348 hasConceptScore W2086749348C203014093 @default.
• W2086749348 hasConceptScore W2086749348C204787440 @default.
• W2086749348 hasConceptScore W2086749348C207480886 @default.
• W2086749348 hasConceptScore W2086749348C27081682 @default.
• W2086749348 hasConceptScore W2086749348C2776042228 @default.
• W2086749348 hasConceptScore W2086749348C2776178081 @default.
• W2086749348 hasConceptScore W2086749348C2776238763 @default.
• W2086749348 hasConceptScore W2086749348C2776954882 @default.
• W2086749348 hasConceptScore W2086749348C2777714996 @default.
• W2086749348 hasConceptScore W2086749348C2780510475 @default.
• W2086749348 hasConceptScore W2086749348C42219234 @default.
• W2086749348 hasConceptScore W2086749348C71924100 @default.
• W2086749348 hasConceptScore W2086749348C87813604 @default.
• W2086749348 hasIssue "3" @default.
• W2086749348 hasLocation W20867493481 @default.
• W2086749348 hasLocation W20867493482 @default.
• W2086749348 hasLocation W20867493483 @default.
• W2086749348 hasLocation W20867493484 @default.
• W2086749348 hasOpenAccess W2086749348 @default.
• W2086749348 hasPrimaryLocation W20867493481 @default.
• W2086749348 hasRelatedWork W1997281330 @default.

• next