Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086753614> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2086753614 endingPage "748" @default.
- W2086753614 startingPage "743" @default.
- W2086753614 abstract "Molecular weight distribution is an important quality attribute for hypromellose acetate succinate (HPMCAS), a pharmaceutical excipient used in spray-dried dispersions. Our previous study showed that neither relative nor universal calibration method of size exclusion chromatography (SEC) works for HPMCAS polymers. We here report our effort to develop a SEC method using a mass sensitive multi angle laser light scattering detector (MALLS) to determine molecular weight distributions of HPMCAS polymers. A solvent screen study reveals that a mixed solvent (60:40%, v/v 50 mM NaH2PO4 with 0.1 M NaNO3 buffer: acetonitrile, pH* 8.0) is the best for HPMCAS-LF and MF sub-classes. Use of a mixed solvent creates a challenging condition for the method that uses refractive index detector. Therefore, we thoroughly evaluated the method performance and robustness. The mean weight average molecular weight of a polyethylene oxide standard has a 95% confidence interval of (28,443–28,793) g/mol vs. 28,700 g/mol from the Certificate of Analysis. The relative standard deviations of average molecular weights for all polymers are 3–6%. These results and the Design of Experiments study demonstrate that the method is accurate and robust." @default.
- W2086753614 created "2016-06-24" @default.
- W2086753614 creator A5010830075 @default.
- W2086753614 creator A5030972763 @default.
- W2086753614 creator A5080379239 @default.
- W2086753614 date "2011-12-01" @default.
- W2086753614 modified "2023-09-23" @default.
- W2086753614 title "Absolute molecular weight determination of hypromellose acetate succinate by size exclusion chromatography: Use of a multi angle laser light scattering detector and a mixed solvent" @default.
- W2086753614 cites W1965875842 @default.
- W2086753614 cites W1976437481 @default.
- W2086753614 cites W2017948516 @default.
- W2086753614 cites W2023045528 @default.
- W2086753614 cites W2041517295 @default.
- W2086753614 cites W2049248450 @default.
- W2086753614 cites W2050102331 @default.
- W2086753614 cites W2081800783 @default.
- W2086753614 cites W2100861268 @default.
- W2086753614 cites W2110680433 @default.
- W2086753614 cites W2121780278 @default.
- W2086753614 cites W2162819692 @default.
- W2086753614 doi "https://doi.org/10.1016/j.jpba.2011.07.035" @default.
- W2086753614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21840663" @default.
- W2086753614 hasPublicationYear "2011" @default.
- W2086753614 type Work @default.
- W2086753614 sameAs 2086753614 @default.
- W2086753614 citedByCount "17" @default.
- W2086753614 countsByYear W20867536142013 @default.
- W2086753614 countsByYear W20867536142014 @default.
- W2086753614 countsByYear W20867536142015 @default.
- W2086753614 countsByYear W20867536142017 @default.
- W2086753614 countsByYear W20867536142018 @default.
- W2086753614 countsByYear W20867536142020 @default.
- W2086753614 crossrefType "journal-article" @default.
- W2086753614 hasAuthorship W2086753614A5010830075 @default.
- W2086753614 hasAuthorship W2086753614A5030972763 @default.
- W2086753614 hasAuthorship W2086753614A5080379239 @default.
- W2086753614 hasConcept C113196181 @default.
- W2086753614 hasConcept C158117686 @default.
- W2086753614 hasConcept C178790620 @default.
- W2086753614 hasConcept C181199279 @default.
- W2086753614 hasConcept C185592680 @default.
- W2086753614 hasConcept C193363816 @default.
- W2086753614 hasConcept C2777463227 @default.
- W2086753614 hasConcept C2780471494 @default.
- W2086753614 hasConcept C43617362 @default.
- W2086753614 hasConcept C521977710 @default.
- W2086753614 hasConceptScore W2086753614C113196181 @default.
- W2086753614 hasConceptScore W2086753614C158117686 @default.
- W2086753614 hasConceptScore W2086753614C178790620 @default.
- W2086753614 hasConceptScore W2086753614C181199279 @default.
- W2086753614 hasConceptScore W2086753614C185592680 @default.
- W2086753614 hasConceptScore W2086753614C193363816 @default.
- W2086753614 hasConceptScore W2086753614C2777463227 @default.
- W2086753614 hasConceptScore W2086753614C2780471494 @default.
- W2086753614 hasConceptScore W2086753614C43617362 @default.
- W2086753614 hasConceptScore W2086753614C521977710 @default.
- W2086753614 hasIssue "4" @default.
- W2086753614 hasLocation W20867536141 @default.
- W2086753614 hasLocation W20867536142 @default.
- W2086753614 hasOpenAccess W2086753614 @default.
- W2086753614 hasPrimaryLocation W20867536141 @default.
- W2086753614 hasRelatedWork W1968824668 @default.
- W2086753614 hasRelatedWork W1980115234 @default.
- W2086753614 hasRelatedWork W2040755630 @default.
- W2086753614 hasRelatedWork W2064579062 @default.
- W2086753614 hasRelatedWork W2075139655 @default.
- W2086753614 hasRelatedWork W2123462530 @default.
- W2086753614 hasRelatedWork W2169543333 @default.
- W2086753614 hasRelatedWork W2196784596 @default.
- W2086753614 hasRelatedWork W2282687875 @default.
- W2086753614 hasRelatedWork W2479247803 @default.
- W2086753614 hasVolume "56" @default.
- W2086753614 isParatext "false" @default.
- W2086753614 isRetracted "false" @default.
- W2086753614 magId "2086753614" @default.
- W2086753614 workType "article" @default.