Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086756871> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2086756871 endingPage "650" @default.
- W2086756871 startingPage "644" @default.
- W2086756871 abstract "A series of fourteen 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues were synthesized and evaluated for anticonvulsant activity according to the Antiepileptic Drug Development Programme (ADD) protocol. Some of the synthesized compounds showed significant activity in minimal clonic seizure model (6 Hz psychomotor seizure test). 3-(4-Fluorophenyl)-N-(4-bromophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (4c) was found to be the most active compound of the series showing 75% (3/4, 0.25-2.0 h) and 50% (2/4, 4.0 h) protection against minimal clonic seizure at 100 mg/kg without any toxicity. 3-(Pyridin-4-yl)-N-(4-chlorophenyl)-6,7-dimethoxy-3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide (4f) showed protection in maximal electroshock (MES) seizure and subcutaneous metrazol (scMET) seizure at 300 mg/kg." @default.
- W2086756871 created "2016-06-24" @default.
- W2086756871 creator A5028091551 @default.
- W2086756871 creator A5031331094 @default.
- W2086756871 creator A5067088727 @default.
- W2086756871 creator A5089198047 @default.
- W2086756871 date "2012-03-07" @default.
- W2086756871 modified "2023-09-25" @default.
- W2086756871 title "Synthesis and anticonvulsant activity of 3a,4-dihydro-3H-indeno[1,2-c]pyrazole-2-carboxamide/carbothioamide analogues" @default.
- W2086756871 cites W1547367931 @default.
- W2086756871 cites W1548124393 @default.
- W2086756871 cites W1974777442 @default.
- W2086756871 cites W1988476821 @default.
- W2086756871 cites W1991684091 @default.
- W2086756871 cites W1992517221 @default.
- W2086756871 cites W1996670920 @default.
- W2086756871 cites W2005724145 @default.
- W2086756871 cites W2018021139 @default.
- W2086756871 cites W2063019439 @default.
- W2086756871 cites W2077959898 @default.
- W2086756871 cites W2083741306 @default.
- W2086756871 cites W2100283245 @default.
- W2086756871 cites W2104095503 @default.
- W2086756871 cites W2129829319 @default.
- W2086756871 cites W2174189900 @default.
- W2086756871 cites W2951775377 @default.
- W2086756871 doi "https://doi.org/10.3109/14756366.2012.663364" @default.
- W2086756871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22397394" @default.
- W2086756871 hasPublicationYear "2012" @default.
- W2086756871 type Work @default.
- W2086756871 sameAs 2086756871 @default.
- W2086756871 citedByCount "23" @default.
- W2086756871 countsByYear W20867568712012 @default.
- W2086756871 countsByYear W20867568712013 @default.
- W2086756871 countsByYear W20867568712015 @default.
- W2086756871 countsByYear W20867568712016 @default.
- W2086756871 countsByYear W20867568712017 @default.
- W2086756871 countsByYear W20867568712018 @default.
- W2086756871 countsByYear W20867568712019 @default.
- W2086756871 countsByYear W20867568712020 @default.
- W2086756871 countsByYear W20867568712021 @default.
- W2086756871 countsByYear W20867568712022 @default.
- W2086756871 crossrefType "journal-article" @default.
- W2086756871 hasAuthorship W2086756871A5028091551 @default.
- W2086756871 hasAuthorship W2086756871A5031331094 @default.
- W2086756871 hasAuthorship W2086756871A5067088727 @default.
- W2086756871 hasAuthorship W2086756871A5089198047 @default.
- W2086756871 hasConcept C118552586 @default.
- W2086756871 hasConcept C155647269 @default.
- W2086756871 hasConcept C178790620 @default.
- W2086756871 hasConcept C185592680 @default.
- W2086756871 hasConcept C2775858608 @default.
- W2086756871 hasConcept C2777682936 @default.
- W2086756871 hasConcept C2778186239 @default.
- W2086756871 hasConcept C2778327999 @default.
- W2086756871 hasConcept C29730261 @default.
- W2086756871 hasConcept C71240020 @default.
- W2086756871 hasConcept C71924100 @default.
- W2086756871 hasConcept C98274493 @default.
- W2086756871 hasConceptScore W2086756871C118552586 @default.
- W2086756871 hasConceptScore W2086756871C155647269 @default.
- W2086756871 hasConceptScore W2086756871C178790620 @default.
- W2086756871 hasConceptScore W2086756871C185592680 @default.
- W2086756871 hasConceptScore W2086756871C2775858608 @default.
- W2086756871 hasConceptScore W2086756871C2777682936 @default.
- W2086756871 hasConceptScore W2086756871C2778186239 @default.
- W2086756871 hasConceptScore W2086756871C2778327999 @default.
- W2086756871 hasConceptScore W2086756871C29730261 @default.
- W2086756871 hasConceptScore W2086756871C71240020 @default.
- W2086756871 hasConceptScore W2086756871C71924100 @default.
- W2086756871 hasConceptScore W2086756871C98274493 @default.
- W2086756871 hasIssue "3" @default.
- W2086756871 hasLocation W20867568711 @default.
- W2086756871 hasLocation W20867568712 @default.
- W2086756871 hasOpenAccess W2086756871 @default.
- W2086756871 hasPrimaryLocation W20867568711 @default.
- W2086756871 hasRelatedWork W1985552599 @default.
- W2086756871 hasRelatedWork W2004537161 @default.
- W2086756871 hasRelatedWork W2060064011 @default.
- W2086756871 hasRelatedWork W2086756871 @default.
- W2086756871 hasRelatedWork W2431487876 @default.
- W2086756871 hasRelatedWork W2947141021 @default.
- W2086756871 hasRelatedWork W2952804201 @default.
- W2086756871 hasRelatedWork W2953386856 @default.
- W2086756871 hasRelatedWork W3048217223 @default.
- W2086756871 hasRelatedWork W2083622052 @default.
- W2086756871 hasVolume "28" @default.
- W2086756871 isParatext "false" @default.
- W2086756871 isRetracted "false" @default.
- W2086756871 magId "2086756871" @default.
- W2086756871 workType "article" @default.