FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086765622> ?p ?o ?g. }

• W2086765622 endingPage "236" @default.
• W2086765622 startingPage "229" @default.
• W2086765622 abstract "A systematic investigation of the polymorph−hydrate system for Compound I was carried out with the objective of understanding the phase relationships between the different forms as it relates to crystallization conditions. The ternary phase diagram was determined from solubility and KF measurements of the supernatant liquor for Compound I−water−ethanol mixtures. Water concentrations were converted to water activities using the NRTL-RK model as implemented in ASPEN Properties. These water activities were then used in defining phase boundaries between anhydrous and the various hydrated forms of Compound I. Since the critical water activity at the phase boundaries between anhydrous and hydrated forms in water−cosolvent systems is independent of the nature of the cosolvent it can be used to extrapolate the water concentrations defining ternary phase boundaries in any other cosolvent−water system. This was demonstrated in the cases of acetonitrile−water and dimethyl acetamide−water. Triple points (anhydrate−hydrate−solvent) were estimated in these two cosolvent−water systems. Two representative crystallizations in these crystallization solvents produced a hemihydrate in 15% acetonitrile−water, and the tetrahydrate in 15% dimethyl acetamide−water, both of which were predicted by the phase diagrams in these systems. The importance of this work lies in obviating the need for phase equilibria measurements in every cosolvent−water system used in crystallization processes. Additionally the crystal structure of hemihydrate was solved by single-crystal X-ray diffraction, and the binding mode of water in the lattice elucidates the thermal and hygroscopicity behavior of this form. In addition the crystal structure unambiguously identified the hemihydrate and enabled the design on an appropriate crystallization process incorporating aw as a major variable." @default.
• W2086765622 created "2016-06-24" @default.
• W2086765622 creator A5014256057 @default.
• W2086765622 creator A5025998077 @default.
• W2086765622 creator A5027639058 @default.
• W2086765622 creator A5047982691 @default.
• W2086765622 creator A5056532797 @default.
• W2086765622 creator A5065122830 @default.
• W2086765622 date "2007-03-01" @default.
• W2086765622 modified "2023-10-16" @default.
• W2086765622 title "Water Activity-Mediated Control of Crystalline Phases of an Active Pharmaceutical Ingredient" @default.
• W2086765622 cites W2003341912 @default.
• W2086765622 cites W2009402446 @default.
• W2086765622 cites W2020247027 @default.
• W2086765622 cites W2021231996 @default.
• W2086765622 cites W2036018205 @default.
• W2086765622 cites W2057302806 @default.
• W2086765622 cites W2086622416 @default.
• W2086765622 cites W2103821506 @default.
• W2086765622 cites W2129687914 @default.
• W2086765622 cites W2170757190 @default.
• W2086765622 cites W3022786532 @default.
• W2086765622 cites W4230831096 @default.
• W2086765622 cites W4247665233 @default.
• W2086765622 doi "https://doi.org/10.1021/op600277t" @default.
• W2086765622 hasPublicationYear "2007" @default.
• W2086765622 type Work @default.
• W2086765622 sameAs 2086765622 @default.
• W2086765622 citedByCount "39" @default.
• W2086765622 countsByYear W20867656222012 @default.
• W2086765622 countsByYear W20867656222014 @default.
• W2086765622 countsByYear W20867656222015 @default.
• W2086765622 countsByYear W20867656222016 @default.
• W2086765622 countsByYear W20867656222017 @default.
• W2086765622 countsByYear W20867656222018 @default.
• W2086765622 countsByYear W20867656222019 @default.
• W2086765622 countsByYear W20867656222020 @default.
• W2086765622 countsByYear W20867656222021 @default.
• W2086765622 countsByYear W20867656222023 @default.
• W2086765622 crossrefType "journal-article" @default.
• W2086765622 hasAuthorship W2086765622A5014256057 @default.
• W2086765622 hasAuthorship W2086765622A5025998077 @default.
• W2086765622 hasAuthorship W2086765622A5027639058 @default.
• W2086765622 hasAuthorship W2086765622A5047982691 @default.
• W2086765622 hasAuthorship W2086765622A5056532797 @default.
• W2086765622 hasAuthorship W2086765622A5065122830 @default.
• W2086765622 hasConcept C115624301 @default.
• W2086765622 hasConcept C122247533 @default.
• W2086765622 hasConcept C124392266 @default.
• W2086765622 hasConcept C127413603 @default.
• W2086765622 hasConcept C155574463 @default.
• W2086765622 hasConcept C178790620 @default.
• W2086765622 hasConcept C185592680 @default.
• W2086765622 hasConcept C187714232 @default.
• W2086765622 hasConcept C199360897 @default.
• W2086765622 hasConcept C203036418 @default.
• W2086765622 hasConcept C2777463227 @default.
• W2086765622 hasConcept C2780471494 @default.
• W2086765622 hasConcept C2781060337 @default.
• W2086765622 hasConcept C38743072 @default.
• W2086765622 hasConcept C41008148 @default.
• W2086765622 hasConcept C42360764 @default.
• W2086765622 hasConcept C44280652 @default.
• W2086765622 hasConcept C64452783 @default.
• W2086765622 hasConcept C8010536 @default.
• W2086765622 hasConcept C85906118 @default.
• W2086765622 hasConceptScore W2086765622C115624301 @default.
• W2086765622 hasConceptScore W2086765622C122247533 @default.
• W2086765622 hasConceptScore W2086765622C124392266 @default.
• W2086765622 hasConceptScore W2086765622C127413603 @default.
• W2086765622 hasConceptScore W2086765622C155574463 @default.
• W2086765622 hasConceptScore W2086765622C178790620 @default.
• W2086765622 hasConceptScore W2086765622C185592680 @default.
• W2086765622 hasConceptScore W2086765622C187714232 @default.
• W2086765622 hasConceptScore W2086765622C199360897 @default.
• W2086765622 hasConceptScore W2086765622C203036418 @default.
• W2086765622 hasConceptScore W2086765622C2777463227 @default.
• W2086765622 hasConceptScore W2086765622C2780471494 @default.
• W2086765622 hasConceptScore W2086765622C2781060337 @default.
• W2086765622 hasConceptScore W2086765622C38743072 @default.
• W2086765622 hasConceptScore W2086765622C41008148 @default.
• W2086765622 hasConceptScore W2086765622C42360764 @default.
• W2086765622 hasConceptScore W2086765622C44280652 @default.
• W2086765622 hasConceptScore W2086765622C64452783 @default.
• W2086765622 hasConceptScore W2086765622C8010536 @default.
• W2086765622 hasConceptScore W2086765622C85906118 @default.
• W2086765622 hasIssue "2" @default.
• W2086765622 hasLocation W20867656221 @default.
• W2086765622 hasOpenAccess W2086765622 @default.
• W2086765622 hasPrimaryLocation W20867656221 @default.
• W2086765622 hasRelatedWork W1903421706 @default.
• W2086765622 hasRelatedWork W1965743244 @default.
• W2086765622 hasRelatedWork W1998172362 @default.
• W2086765622 hasRelatedWork W2349011040 @default.
• W2086765622 hasRelatedWork W2419040646 @default.
• W2086765622 hasRelatedWork W2463980239 @default.
• W2086765622 hasRelatedWork W2485845547 @default.
• W2086765622 hasRelatedWork W2565875457 @default.

• next