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- W2086768863 abstract "ADAMTS5 (TS5), a member of the aggrecanase clade (TS1, 4, 5, 8, 9, 15) of ADAMTS-proteases, has been considered largely responsible for the proteolysis of the hyalectans, aggrecan (Acan) and versican (Vcan), in vivo. However, we have reported that ts5-knockout (KO) mice show joint protection after injury due to inhibition of synovial scarring and enhanced Acan deposition. Also, KO mice have an impaired wound healing phenotype in skin and tendons which is associated with Acan/Vcan-rich deposits at the wound sites. Moreover, the Acan and Vcan deposited was aggrecanase-cleaved, even in the absence of TS5. In this study, we have used adipose-derived stromal cell (ADSC) and epiphyseal chondrocyte cultures from wild type and KO mice to further study the role of TS5 in Acan and Vcan turnover. We have confirmed with both cell types that the aggrecanase-mediated degradation of these hyalectans is not due to TS5, but an aggrecanase which primarily cleaves them before they are secreted. We also provide data which suggests that TS5 protein functions to suppress glucose uptake in ADSCs and thereby inhibits the synthesis, and promotes the intracellular degradation of Acan and Vcan by an ADAMTS other than TS5. We propose that this apparently non-proteolytic role of TS5 explains its anti-chondrogenic and pro-fibrotic effects in murine models of wound repair. A possible role for TS5 in an endocytotic process, involving competitive interactions between TS5, LRP1 and GLUT4 is discussed." @default.
- W2086768863 created "2016-06-24" @default.
- W2086768863 creator A5011890980 @default.
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- W2086768863 date "2015-09-01" @default.
- W2086768863 modified "2023-10-18" @default.
- W2086768863 title "Deletion of ADAMTS5 does not affect aggrecan or versican degradation but promotes glucose uptake and proteoglycan synthesis in murine adipose derived stromal cells" @default.
- W2086768863 cites W108819721 @default.
- W2086768863 cites W1626846833 @default.
- W2086768863 cites W1660392447 @default.
- W2086768863 cites W1790809173 @default.
- W2086768863 cites W1903604055 @default.
- W2086768863 cites W1926168677 @default.
- W2086768863 cites W1967267708 @default.
- W2086768863 cites W1967510196 @default.
- W2086768863 cites W1971319797 @default.
- W2086768863 cites W1974145152 @default.
- W2086768863 cites W1974472305 @default.
- W2086768863 cites W1977914172 @default.
- W2086768863 cites W1978709727 @default.
- W2086768863 cites W1980773132 @default.
- W2086768863 cites W1982012141 @default.
- W2086768863 cites W1983077307 @default.
- W2086768863 cites W1983618726 @default.
- W2086768863 cites W1985713298 @default.
- W2086768863 cites W1987210971 @default.
- W2086768863 cites W1989061586 @default.
- W2086768863 cites W1990917414 @default.
- W2086768863 cites W1994823840 @default.
- W2086768863 cites W1999497004 @default.
- W2086768863 cites W2000003017 @default.
- W2086768863 cites W2000697736 @default.
- W2086768863 cites W2002793462 @default.
- W2086768863 cites W2002991083 @default.
- W2086768863 cites W2003878474 @default.
- W2086768863 cites W2009266347 @default.
- W2086768863 cites W2011227409 @default.
- W2086768863 cites W2012152900 @default.
- W2086768863 cites W2014041307 @default.
- W2086768863 cites W2015858154 @default.
- W2086768863 cites W2017644547 @default.
- W2086768863 cites W2019627505 @default.
- W2086768863 cites W2022228053 @default.
- W2086768863 cites W2023153920 @default.
- W2086768863 cites W2024229865 @default.
- W2086768863 cites W2024807114 @default.
- W2086768863 cites W2028358054 @default.
- W2086768863 cites W2029210030 @default.
- W2086768863 cites W2029927816 @default.
- W2086768863 cites W2030435937 @default.
- W2086768863 cites W2030989962 @default.
- W2086768863 cites W2032022598 @default.
- W2086768863 cites W2033916067 @default.
- W2086768863 cites W2034720838 @default.
- W2086768863 cites W2035469813 @default.
- W2086768863 cites W2036540051 @default.
- W2086768863 cites W2036838019 @default.
- W2086768863 cites W2038486706 @default.
- W2086768863 cites W2041173066 @default.
- W2086768863 cites W2043482625 @default.
- W2086768863 cites W2043703144 @default.
- W2086768863 cites W2046982555 @default.
- W2086768863 cites W2050345171 @default.
- W2086768863 cites W2052354463 @default.
- W2086768863 cites W2053628893 @default.
- W2086768863 cites W2056046349 @default.
- W2086768863 cites W2057902383 @default.
- W2086768863 cites W2058081151 @default.
- W2086768863 cites W2058577904 @default.
- W2086768863 cites W2067101414 @default.
- W2086768863 cites W2067350937 @default.
- W2086768863 cites W2067509496 @default.
- W2086768863 cites W2070909445 @default.
- W2086768863 cites W2076042473 @default.
- W2086768863 cites W2079284505 @default.
- W2086768863 cites W2080270214 @default.
- W2086768863 cites W2081078677 @default.
- W2086768863 cites W2085473892 @default.
- W2086768863 cites W2087816256 @default.
- W2086768863 cites W2090243702 @default.
- W2086768863 cites W2095099053 @default.
- W2086768863 cites W2096352098 @default.
- W2086768863 cites W2105599853 @default.
- W2086768863 cites W2110141676 @default.
- W2086768863 cites W2120073615 @default.
- W2086768863 cites W2121535505 @default.
- W2086768863 cites W2127507893 @default.
- W2086768863 cites W2128742610 @default.
- W2086768863 cites W2129281935 @default.
- W2086768863 cites W2130192491 @default.
- W2086768863 cites W2133032095 @default.
- W2086768863 cites W2133109532 @default.