Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086770126> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2086770126 endingPage "445" @default.
- W2086770126 startingPage "437" @default.
- W2086770126 abstract "A method for administration of highly toxic chemicals by inhalation was developed. The model has three features of special interest: (1) a diffusion cell for producing a constant gas concentration, if necessary for several hours and days, (2) a small rapidly equilibrated inhalation chamber (1100 ml), and (3) complete isolation of the toxic chemicals from the atmosphere. The LCt50 of the anticholinesterase soman [o-(1,2,2 trimethylpropyl)-methyl-phosphonofluoridate] was 400 mg min/m3, registered 24 hr after the end of exposure. The lethal concentration X time of soman was 520 +/- 60 mg min/m3 when exposing the animals until death in the inhalation chamber. The exposure was less than 30 min and the concentration of soman was 21 mg/m3. The inhibition of acetylcholinesterase, cholinesterase, and carboxylesterase activities in different tissues was analyzed to study the possible barrier mechanisms that might exist in the body to soman. There was a large inhibition of the carboxylesterase and cholinesterase activities in bronchi and lungs as well as in blood. Carboxylesterases were important as detoxifying enzymes, as shown by 70% enhancement in toxicity of soman following sc pretreatment with TOCP (tri-ortho-cresyl-phosphate), a carboxylesterase inhibitor." @default.
- W2086770126 created "2016-06-24" @default.
- W2086770126 creator A5022652887 @default.
- W2086770126 creator A5023330531 @default.
- W2086770126 creator A5039116931 @default.
- W2086770126 creator A5040751788 @default.
- W2086770126 date "1985-09-01" @default.
- W2086770126 modified "2023-09-27" @default.
- W2086770126 title "A method for generating toxic vapors of soman: Toxicity of soman by inhalation in rats" @default.
- W2086770126 cites W1971570487 @default.
- W2086770126 cites W1972737444 @default.
- W2086770126 cites W1975327670 @default.
- W2086770126 cites W1982972545 @default.
- W2086770126 cites W1999825629 @default.
- W2086770126 cites W2020359825 @default.
- W2086770126 cites W2022904634 @default.
- W2086770126 cites W2053136377 @default.
- W2086770126 cites W2055225004 @default.
- W2086770126 cites W2073216966 @default.
- W2086770126 cites W2121453836 @default.
- W2086770126 cites W2132530930 @default.
- W2086770126 doi "https://doi.org/10.1016/0041-008x(85)90388-6" @default.
- W2086770126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4035697" @default.
- W2086770126 hasPublicationYear "1985" @default.
- W2086770126 type Work @default.
- W2086770126 sameAs 2086770126 @default.
- W2086770126 citedByCount "27" @default.
- W2086770126 countsByYear W20867701262012 @default.
- W2086770126 crossrefType "journal-article" @default.
- W2086770126 hasAuthorship W2086770126A5022652887 @default.
- W2086770126 hasAuthorship W2086770126A5023330531 @default.
- W2086770126 hasAuthorship W2086770126A5039116931 @default.
- W2086770126 hasAuthorship W2086770126A5040751788 @default.
- W2086770126 hasConcept C178790620 @default.
- W2086770126 hasConcept C181199279 @default.
- W2086770126 hasConcept C185592680 @default.
- W2086770126 hasConcept C2776954882 @default.
- W2086770126 hasConcept C2778325069 @default.
- W2086770126 hasConcept C2778706303 @default.
- W2086770126 hasConcept C2778816929 @default.
- W2086770126 hasConcept C2779777708 @default.
- W2086770126 hasConcept C2780266723 @default.
- W2086770126 hasConcept C29730261 @default.
- W2086770126 hasConcept C31896038 @default.
- W2086770126 hasConcept C33070731 @default.
- W2086770126 hasConcept C42219234 @default.
- W2086770126 hasConcept C55493867 @default.
- W2086770126 hasConcept C71924100 @default.
- W2086770126 hasConcept C86803240 @default.
- W2086770126 hasConcept C98274493 @default.
- W2086770126 hasConceptScore W2086770126C178790620 @default.
- W2086770126 hasConceptScore W2086770126C181199279 @default.
- W2086770126 hasConceptScore W2086770126C185592680 @default.
- W2086770126 hasConceptScore W2086770126C2776954882 @default.
- W2086770126 hasConceptScore W2086770126C2778325069 @default.
- W2086770126 hasConceptScore W2086770126C2778706303 @default.
- W2086770126 hasConceptScore W2086770126C2778816929 @default.
- W2086770126 hasConceptScore W2086770126C2779777708 @default.
- W2086770126 hasConceptScore W2086770126C2780266723 @default.
- W2086770126 hasConceptScore W2086770126C29730261 @default.
- W2086770126 hasConceptScore W2086770126C31896038 @default.
- W2086770126 hasConceptScore W2086770126C33070731 @default.
- W2086770126 hasConceptScore W2086770126C42219234 @default.
- W2086770126 hasConceptScore W2086770126C55493867 @default.
- W2086770126 hasConceptScore W2086770126C71924100 @default.
- W2086770126 hasConceptScore W2086770126C86803240 @default.
- W2086770126 hasConceptScore W2086770126C98274493 @default.
- W2086770126 hasIssue "3" @default.
- W2086770126 hasLocation W20867701261 @default.
- W2086770126 hasLocation W20867701262 @default.
- W2086770126 hasOpenAccess W2086770126 @default.
- W2086770126 hasPrimaryLocation W20867701261 @default.
- W2086770126 hasRelatedWork W1976955739 @default.
- W2086770126 hasRelatedWork W1986494743 @default.
- W2086770126 hasRelatedWork W1987587236 @default.
- W2086770126 hasRelatedWork W2012007695 @default.
- W2086770126 hasRelatedWork W2019049150 @default.
- W2086770126 hasRelatedWork W2058292682 @default.
- W2086770126 hasRelatedWork W2077179629 @default.
- W2086770126 hasRelatedWork W2086770126 @default.
- W2086770126 hasRelatedWork W2385867839 @default.
- W2086770126 hasRelatedWork W310720149 @default.
- W2086770126 hasVolume "80" @default.
- W2086770126 isParatext "false" @default.
- W2086770126 isRetracted "false" @default.
- W2086770126 magId "2086770126" @default.
- W2086770126 workType "article" @default.