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- W2086786384 abstract "The effects of aphidicolin – a powerful inhibitor of DNA polymerase α and of DNA replication – on normal development and on differentiation without cleavage of Chaetopterus eggs have been studied with cytological, cytochemical, and biochemical methods. The experiments show that the initial period of pseudocleavage can take place in the absence of nuclear DNA synthesis, but further development (segregation, hatching, ciliation) requires DNA synthesis. However ciliated unicellular larvae can be obtained under conditions where the DNA content of the embryos in only 40% of the controls. In fertilized eggs, aphidicolin immediately stops cleavage. The significance of these results is discussed." @default.
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- W2086786384 date "1981-09-01" @default.
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- W2086786384 title "Studies on Differentiation without Cleavage in Chaetopterus: Effects of Inhibition of DNA Synthesis with Aphidicolin" @default.
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- W2086786384 doi "https://doi.org/10.1111/j.1432-0436.1981.tb01126.x" @default.
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