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- W2086798447 abstract "The cases of anthrax that accompanied the postal attacks in 2001 confirm that biologic weapons can and will be used against civilian populations. 1 Jernigan DB, Raghunathan PL, Bell BP, Brechner R, Bresnitz EA, Butler JC. Investigation of bioterrorism-related anthrax, United States, 2001: epidemiologic findings. Emerg Infect Dis 2002;8:1019-28 Google Scholar Smallpox has the same potential and has been weaponized to serve as a biologic weapon. 2 Henderson D.A. The looming threat of bioterrorism. Science. 1999; 283: 1279-1282 Google Scholar As a result, the US government has committed substantial resources to assure broad access to the current vaccine and to develop new vaccines to defend against this possibility. In this review, we summarize the production, composition, application, indications and contraindications of the current commercially available smallpox vaccine Dryvax (Wyeth Laboratories, Inc, Madison, NJ). In addition, we highlight innovative features of new smallpox vaccines and consider how advances in vaccine technology may lead to the successful creation of improved smallpox vaccines. Table I Table ICurrent and future live virus smallpox vaccines Vaccine source Vaccinia virus strain Production Availability Dryvax, Wyeth NYCBOH Infected calves 15 million doses, undiluted Aventis-Pasteur NYCBOH Infected calves 75-90 million doses, undiluted Acam1000 NYCBOH MRC-5 cells Phase 2 clinical trial Acam2000 NYCBOH Vero cells Phase 1 clinical trial DynPort NYCBOH MRC-5 cells Phase 1 clinical trial NIH MVA Chicken-embryo fibroblast cells Phase 1 clinical trial VaxGen and Kaketsuken LC16m8 Rabbit-kidney cells Phase 1 clinical trial Open table in a new tab" @default.
- W2086798447 created "2016-06-24" @default.
- W2086798447 creator A5003815634 @default.
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- W2086798447 date "2003-10-01" @default.
- W2086798447 modified "2023-09-27" @default.
- W2086798447 title "Smallpox vaccines: Current and future" @default.
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- W2086798447 doi "https://doi.org/10.1016/s0022-2143(03)00143-4" @default.
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