FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086812345> ?p ?o ?g. }

• W2086812345 endingPage "113" @default.
• W2086812345 startingPage "101" @default.
• W2086812345 abstract "Protein inhibitor of activated STAT1 (PIAS1) was shown to play an important role in inflammation and innate immune response, but how PIAS1 is regulated is not known. We have recently demonstrated that PIAS1 enhances spatial learning and memory performance in rats. In this study, we examined the signaling pathway and neural mechanism that regulate PIAS1 expression in the brain by using pharmacological and molecular approaches. Our results revealed that pias1 gene expression is rapidly induced upon NMDA receptor activation in rat hippocampus, but this effect is blocked by transfection of sub-threshold concentrations of ERK1 siRNA/ERK2 siRNA or CREB siRNA. Pias1 gene expression is similarly induced by overexpression of the ERK1/ERK2 plasmids in rat hippocampus, and this effect is also blocked by sub-threshold concentration of CREB siRNA transfection. On the other hand, transfection of ERK1 siRNA/ERK2 siRNA or CREB siRNA at a higher concentration is sufficient to down-regulate PIAS1 expression. Inhibition of PI-3 kinase signaling and CaMKII signaling, which both result in CREB inactivation, similarly decreases PIAS1 expression. But NMDA and MK-801 do not affect the expression of IL-6 and TNFα. NMDA also did not affect the expression of PIAS2, PIAS3 and PIAS4. Further, pias1 mRNA has a similar degradation rate to that of the zif268 gene. These results together suggest that pias1 may function as an immediate early gene in an activity-dependent manner and PIAS1 expression is regulated by the NMDA-MAPK/ERK-CREB signaling pathway implicated in neuronal plasticity." @default.
• W2086812345 created "2016-06-24" @default.
• W2086812345 creator A5065058126 @default.
• W2086812345 creator A5087273729 @default.
• W2086812345 creator A5087597869 @default.
• W2086812345 date "2013-02-01" @default.
• W2086812345 modified "2023-09-27" @default.
• W2086812345 title "NMDA receptor signaling mediates the expression of protein inhibitor of activated STAT1 (PIAS1) in rat hippocampus" @default.
• W2086812345 cites W1504375431 @default.
• W2086812345 cites W1660095449 @default.
• W2086812345 cites W1708150772 @default.
• W2086812345 cites W173488229 @default.
• W2086812345 cites W1966280980 @default.
• W2086812345 cites W1984466510 @default.
• W2086812345 cites W1985723042 @default.
• W2086812345 cites W1986908032 @default.
• W2086812345 cites W1990264946 @default.
• W2086812345 cites W1991601985 @default.
• W2086812345 cites W1993583458 @default.
• W2086812345 cites W1995456120 @default.
• W2086812345 cites W1995792679 @default.
• W2086812345 cites W1998977808 @default.
• W2086812345 cites W2002632293 @default.
• W2086812345 cites W2016166905 @default.
• W2086812345 cites W2017197221 @default.
• W2086812345 cites W2021848117 @default.
• W2086812345 cites W2024207939 @default.
• W2086812345 cites W2025204726 @default.
• W2086812345 cites W2028594041 @default.
• W2086812345 cites W2042966900 @default.
• W2086812345 cites W2045263299 @default.
• W2086812345 cites W2047148152 @default.
• W2086812345 cites W2048928172 @default.
• W2086812345 cites W2054879089 @default.
• W2086812345 cites W2074054937 @default.
• W2086812345 cites W2075361934 @default.
• W2086812345 cites W2096370405 @default.
• W2086812345 cites W2107277218 @default.
• W2086812345 cites W2122294619 @default.
• W2086812345 cites W2124432707 @default.
• W2086812345 cites W2133208251 @default.
• W2086812345 cites W2133758473 @default.
• W2086812345 cites W2133850147 @default.
• W2086812345 cites W2136315777 @default.
• W2086812345 cites W2137385309 @default.
• W2086812345 cites W2147865760 @default.
• W2086812345 cites W2152544605 @default.
• W2086812345 cites W2160765931 @default.
• W2086812345 cites W2167753518 @default.
• W2086812345 cites W2169294911 @default.
• W2086812345 cites W2170620920 @default.
• W2086812345 doi "https://doi.org/10.1016/j.neuropharm.2012.08.024" @default.
• W2086812345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22982248" @default.
• W2086812345 hasPublicationYear "2013" @default.
• W2086812345 type Work @default.
• W2086812345 sameAs 2086812345 @default.
• W2086812345 citedByCount "7" @default.
• W2086812345 countsByYear W20868123452014 @default.
• W2086812345 countsByYear W20868123452016 @default.
• W2086812345 countsByYear W20868123452017 @default.
• W2086812345 countsByYear W20868123452019 @default.
• W2086812345 countsByYear W20868123452021 @default.
• W2086812345 countsByYear W20868123452023 @default.
• W2086812345 crossrefType "journal-article" @default.
• W2086812345 hasAuthorship W2086812345A5065058126 @default.
• W2086812345 hasAuthorship W2086812345A5087273729 @default.
• W2086812345 hasAuthorship W2086812345A5087597869 @default.
• W2086812345 hasConcept C104317684 @default.
• W2086812345 hasConcept C153911025 @default.
• W2086812345 hasConcept C1629964 @default.
• W2086812345 hasConcept C173396325 @default.
• W2086812345 hasConcept C185592680 @default.
• W2086812345 hasConcept C22615655 @default.
• W2086812345 hasConcept C2777003663 @default.
• W2086812345 hasConcept C502942594 @default.
• W2086812345 hasConcept C54009773 @default.
• W2086812345 hasConcept C55493867 @default.
• W2086812345 hasConcept C57074206 @default.
• W2086812345 hasConcept C62478195 @default.
• W2086812345 hasConcept C86339819 @default.
• W2086812345 hasConcept C86803240 @default.
• W2086812345 hasConcept C95444343 @default.
• W2086812345 hasConceptScore W2086812345C104317684 @default.
• W2086812345 hasConceptScore W2086812345C153911025 @default.
• W2086812345 hasConceptScore W2086812345C1629964 @default.
• W2086812345 hasConceptScore W2086812345C173396325 @default.
• W2086812345 hasConceptScore W2086812345C185592680 @default.
• W2086812345 hasConceptScore W2086812345C22615655 @default.
• W2086812345 hasConceptScore W2086812345C2777003663 @default.
• W2086812345 hasConceptScore W2086812345C502942594 @default.
• W2086812345 hasConceptScore W2086812345C54009773 @default.
• W2086812345 hasConceptScore W2086812345C55493867 @default.
• W2086812345 hasConceptScore W2086812345C57074206 @default.
• W2086812345 hasConceptScore W2086812345C62478195 @default.
• W2086812345 hasConceptScore W2086812345C86339819 @default.
• W2086812345 hasConceptScore W2086812345C86803240 @default.
• W2086812345 hasConceptScore W2086812345C95444343 @default.
• W2086812345 hasFunder F4320321040 @default.

• next