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- W2086829937 abstract "Toll-like receptors modulate many aspects of the innate immune response. Recent reports suggest that the maturation of phagosomes following particle uptake is modulated through signaling of Toll-like receptors. In the current study, the kinetics of phagosome maturation was evaluated quantitatively by ratio fluorometry to determine the lumenal pH of the phagosomes and a FRET-based technique to determine the degree of phagosome/lysosome fusion. Profiles generated for phagosomes containing experimental particles with or without the TLR ligands Pam3Cys-Ser-(Lys)4 or LPS failed to reveal a difference in maturation despite activating TLR-signaling pathways. Moreover, while macrophages defective in individual TLRs generated phagosome maturation profiles identical to wild-type macrophages, MyD88-deficient macrophages exhibited a marked depression in phagosome/lysosome fusion that appears independent of short-term TLR-mediated effects. The results demonstrate that the rate of maturation of phagosomes proceeds independently of TLR signaling pathways." @default.
- W2086829937 created "2016-06-24" @default.
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- W2086829937 date "2005-10-01" @default.
- W2086829937 modified "2023-10-08" @default.
- W2086829937 title "Phagosome Maturation Proceeds Independently of Stimulation of Toll-like Receptors 2 and 4" @default.
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- W2086829937 doi "https://doi.org/10.1016/j.immuni.2005.09.007" @default.
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