FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086831735> ?p ?o ?g. }

• W2086831735 endingPage "211" @default.
• W2086831735 startingPage "203" @default.
• W2086831735 abstract "How T cells translate T cell receptor (TCR) recognition of almost identical pMHC ligands into distinct biological responses has remained enigmatic. Although differences in affinity or off rate are important, they offer at best an incomplete explanation. By using Förster resonance energy transfer (FRET), we have visualized the ligand-induced interaction between OT-I TCR and CD8. We found that both recruitment of TCR to the immunological synapse and the TCR-CD8 interaction induced by weak agonists (positive-selecting ligands) was delayed but not necessarily weaker than strong agonists (negative selectors). A delayed and perhaps longer lasting CD8-TCR interaction results in delayed phospho-ERK recruitment to the synapse. The kinetics of the TCR-CD8 interaction can reconcile previously anomalous data, where biological activity did not correlate with TCR-pMHC binding kinetics for certain ligands. Our findings indicate that the T cell translates antigen recognition into T cell responses by differential recruitment of CD8 to the TCR." @default.
• W2086831735 created "2016-06-24" @default.
• W2086831735 creator A5055405970 @default.
• W2086831735 creator A5055497014 @default.
• W2086831735 creator A5086083867 @default.
• W2086831735 creator A5087385646 @default.
• W2086831735 date "2006-08-01" @default.
• W2086831735 modified "2023-09-26" @default.
• W2086831735 title "Altered Peptide Ligands Induce Delayed CD8-T Cell Receptor Interaction—a Role for CD8 in Distinguishing Antigen Quality" @default.
• W2086831735 cites W1497032543 @default.
• W2086831735 cites W1614901871 @default.
• W2086831735 cites W1959677146 @default.
• W2086831735 cites W1963569988 @default.
• W2086831735 cites W1963594770 @default.
• W2086831735 cites W1971692004 @default.
• W2086831735 cites W1977225005 @default.
• W2086831735 cites W1977917052 @default.
• W2086831735 cites W1981375452 @default.
• W2086831735 cites W1985298598 @default.
• W2086831735 cites W1995925083 @default.
• W2086831735 cites W2003216771 @default.
• W2086831735 cites W2006629564 @default.
• W2086831735 cites W2009781034 @default.
• W2086831735 cites W2021636987 @default.
• W2086831735 cites W2022204362 @default.
• W2086831735 cites W2037893240 @default.
• W2086831735 cites W2044311894 @default.
• W2086831735 cites W2048159226 @default.
• W2086831735 cites W2057801890 @default.
• W2086831735 cites W2063711348 @default.
• W2086831735 cites W2068924803 @default.
• W2086831735 cites W2082712562 @default.
• W2086831735 cites W2104011738 @default.
• W2086831735 cites W2105130781 @default.
• W2086831735 cites W2114569569 @default.
• W2086831735 cites W2127669953 @default.
• W2086831735 cites W2129134079 @default.
• W2086831735 cites W2130433329 @default.
• W2086831735 cites W2133944986 @default.
• W2086831735 cites W2142581274 @default.
• W2086831735 cites W2145661576 @default.
• W2086831735 cites W2151165347 @default.
• W2086831735 cites W2762980752 @default.
• W2086831735 doi "https://doi.org/10.1016/j.immuni.2006.05.015" @default.
• W2086831735 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16872849" @default.
• W2086831735 hasPublicationYear "2006" @default.
• W2086831735 type Work @default.
• W2086831735 sameAs 2086831735 @default.
• W2086831735 citedByCount "96" @default.
• W2086831735 countsByYear W20868317352012 @default.
• W2086831735 countsByYear W20868317352013 @default.
• W2086831735 countsByYear W20868317352014 @default.
• W2086831735 countsByYear W20868317352015 @default.
• W2086831735 countsByYear W20868317352016 @default.
• W2086831735 countsByYear W20868317352017 @default.
• W2086831735 countsByYear W20868317352018 @default.
• W2086831735 countsByYear W20868317352019 @default.
• W2086831735 countsByYear W20868317352020 @default.
• W2086831735 countsByYear W20868317352021 @default.
• W2086831735 countsByYear W20868317352022 @default.
• W2086831735 countsByYear W20868317352023 @default.
• W2086831735 crossrefType "journal-article" @default.
• W2086831735 hasAuthorship W2086831735A5055405970 @default.
• W2086831735 hasAuthorship W2086831735A5055497014 @default.
• W2086831735 hasAuthorship W2086831735A5086083867 @default.
• W2086831735 hasAuthorship W2086831735A5087385646 @default.
• W2086831735 hasBestOaLocation W20868317351 @default.
• W2086831735 hasConcept C116569031 @default.
• W2086831735 hasConcept C121332964 @default.
• W2086831735 hasConcept C12554922 @default.
• W2086831735 hasConcept C147483822 @default.
• W2086831735 hasConcept C148898269 @default.
• W2086831735 hasConcept C154317977 @default.
• W2086831735 hasConcept C167672396 @default.
• W2086831735 hasConcept C170493617 @default.
• W2086831735 hasConcept C19317047 @default.
• W2086831735 hasConcept C202751555 @default.
• W2086831735 hasConcept C203014093 @default.
• W2086831735 hasConcept C2776090121 @default.
• W2086831735 hasConcept C55493867 @default.
• W2086831735 hasConcept C62520636 @default.
• W2086831735 hasConcept C86803240 @default.
• W2086831735 hasConcept C8891405 @default.
• W2086831735 hasConcept C91881484 @default.
• W2086831735 hasConcept C95444343 @default.
• W2086831735 hasConcept C96305047 @default.
• W2086831735 hasConcept C9756297 @default.
• W2086831735 hasConceptScore W2086831735C116569031 @default.
• W2086831735 hasConceptScore W2086831735C121332964 @default.
• W2086831735 hasConceptScore W2086831735C12554922 @default.
• W2086831735 hasConceptScore W2086831735C147483822 @default.
• W2086831735 hasConceptScore W2086831735C148898269 @default.
• W2086831735 hasConceptScore W2086831735C154317977 @default.
• W2086831735 hasConceptScore W2086831735C167672396 @default.
• W2086831735 hasConceptScore W2086831735C170493617 @default.
• W2086831735 hasConceptScore W2086831735C19317047 @default.
• W2086831735 hasConceptScore W2086831735C202751555 @default.
• W2086831735 hasConceptScore W2086831735C203014093 @default.

• next