FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086834997> ?p ?o ?g. }

• W2086834997 endingPage "4714" @default.
• W2086834997 startingPage "4707" @default.
• W2086834997 abstract "Abstract To evaluate the direct effect of adenosine on cytokine-polarized effector T cells, murine type 1 helper T cells (Th1) and type 1 cytotoxic T lymphocytes (Tc1) and Th2/Tc2 cells were generated using an antigen-presenting cell (APC)-free method. Tc1 and Tc2 cells had similar adenosine signaling, as measured by intracellular cyclic AMP (cAMP) increase upon adenosine A2A receptor agonism by CGS21680 (CGS). CGS greatly reduced Tc1 and Tc2 cell interleukin 2 (IL-2) and tumor necrosis factor α (TNF-α) secretion, with nominal effect on interferon γ (IFN-γ) secretion. Tc2 cell IL-4 and IL-5 secretion was not reduced by CGS, and IL-10 secretion was moderately reduced. Agonist-mediated inhibition of IL-2 and TNF-α secretion occurred via A2A receptors, with no involvement of A1, A2B, or A3 receptors. Adenosine agonist concentrations that abrogated cytokine secretion did not inhibit Tc1 or Tc2 cell cytolytic function. Adenosine modulated effector T cells in vivo, as CGS administration reduced CD4+Th1 and CD8+Tc1 cell expansion to alloantigen and, in a separate model, reduced antigen-specific CD4+ Th1 cell numbers. Remarkably, agonist-mediated T-cell inhibition was abrogated by in vivo IL-2 therapy. Adenosine receptor activation therefore preferentially inhibits type I cytokine secretion, most notably IL-2. Modulation of adenosine receptors may thus represent a suitable target primarily for inflammatory conditions mediated by Th1 and Tc1 cells. (Blood. 2005;105: 4707-4714)" @default.
• W2086834997 created "2016-06-24" @default.
• W2086834997 creator A5033757387 @default.
• W2086834997 creator A5036007966 @default.
• W2086834997 creator A5056262281 @default.
• W2086834997 creator A5069989658 @default.
• W2086834997 creator A5074220802 @default.
• W2086834997 creator A5083240643 @default.
• W2086834997 creator A5091587615 @default.
• W2086834997 date "2005-06-15" @default.
• W2086834997 modified "2023-10-15" @default.
• W2086834997 title "Activation of Th1 and Tc1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo" @default.
• W2086834997 cites W1525984439 @default.
• W2086834997 cites W1550435303 @default.
• W2086834997 cites W1557444833 @default.
• W2086834997 cites W161060649 @default.
• W2086834997 cites W1655756854 @default.
• W2086834997 cites W1831744086 @default.
• W2086834997 cites W1845629018 @default.
• W2086834997 cites W1966370175 @default.
• W2086834997 cites W1975021657 @default.
• W2086834997 cites W1990113288 @default.
• W2086834997 cites W1991255999 @default.
• W2086834997 cites W1995511825 @default.
• W2086834997 cites W2011302684 @default.
• W2086834997 cites W2011765202 @default.
• W2086834997 cites W2018557026 @default.
• W2086834997 cites W2029492709 @default.
• W2086834997 cites W2030261077 @default.
• W2086834997 cites W2038434279 @default.
• W2086834997 cites W2043029488 @default.
• W2086834997 cites W2058990846 @default.
• W2086834997 cites W2071368114 @default.
• W2086834997 cites W2098136315 @default.
• W2086834997 cites W2116238347 @default.
• W2086834997 cites W2122541507 @default.
• W2086834997 cites W2124621398 @default.
• W2086834997 cites W2130183546 @default.
• W2086834997 cites W4248766507 @default.
• W2086834997 doi "https://doi.org/10.1182/blood-2004-04-1407" @default.
• W2086834997 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1895001" @default.
• W2086834997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15746085" @default.
• W2086834997 hasPublicationYear "2005" @default.
• W2086834997 type Work @default.
• W2086834997 sameAs 2086834997 @default.
• W2086834997 citedByCount "129" @default.
• W2086834997 countsByYear W20868349972012 @default.
• W2086834997 countsByYear W20868349972013 @default.
• W2086834997 countsByYear W20868349972014 @default.
• W2086834997 countsByYear W20868349972015 @default.
• W2086834997 countsByYear W20868349972016 @default.
• W2086834997 countsByYear W20868349972017 @default.
• W2086834997 countsByYear W20868349972018 @default.
• W2086834997 countsByYear W20868349972019 @default.
• W2086834997 countsByYear W20868349972020 @default.
• W2086834997 countsByYear W20868349972021 @default.
• W2086834997 countsByYear W20868349972022 @default.
• W2086834997 countsByYear W20868349972023 @default.
• W2086834997 crossrefType "journal-article" @default.
• W2086834997 hasAuthorship W2086834997A5033757387 @default.
• W2086834997 hasAuthorship W2086834997A5036007966 @default.
• W2086834997 hasAuthorship W2086834997A5056262281 @default.
• W2086834997 hasAuthorship W2086834997A5069989658 @default.
• W2086834997 hasAuthorship W2086834997A5074220802 @default.
• W2086834997 hasAuthorship W2086834997A5083240643 @default.
• W2086834997 hasAuthorship W2086834997A5091587615 @default.
• W2086834997 hasBestOaLocation W20868349971 @default.
• W2086834997 hasConcept C126322002 @default.
• W2086834997 hasConcept C134018914 @default.
• W2086834997 hasConcept C154317977 @default.
• W2086834997 hasConcept C158424129 @default.
• W2086834997 hasConcept C170493617 @default.
• W2086834997 hasConcept C202751555 @default.
• W2086834997 hasConcept C203014093 @default.
• W2086834997 hasConcept C2776090121 @default.
• W2086834997 hasConcept C2776991684 @default.
• W2086834997 hasConcept C2778690821 @default.
• W2086834997 hasConcept C2778938600 @default.
• W2086834997 hasConcept C49039625 @default.
• W2086834997 hasConcept C55493867 @default.
• W2086834997 hasConcept C67907053 @default.
• W2086834997 hasConcept C71924100 @default.
• W2086834997 hasConcept C86803240 @default.
• W2086834997 hasConcept C8891405 @default.
• W2086834997 hasConcept C95444343 @default.
• W2086834997 hasConceptScore W2086834997C126322002 @default.
• W2086834997 hasConceptScore W2086834997C134018914 @default.
• W2086834997 hasConceptScore W2086834997C154317977 @default.
• W2086834997 hasConceptScore W2086834997C158424129 @default.
• W2086834997 hasConceptScore W2086834997C170493617 @default.
• W2086834997 hasConceptScore W2086834997C202751555 @default.
• W2086834997 hasConceptScore W2086834997C203014093 @default.
• W2086834997 hasConceptScore W2086834997C2776090121 @default.
• W2086834997 hasConceptScore W2086834997C2776991684 @default.
• W2086834997 hasConceptScore W2086834997C2778690821 @default.
• W2086834997 hasConceptScore W2086834997C2778938600 @default.
• W2086834997 hasConceptScore W2086834997C49039625 @default.
• W2086834997 hasConceptScore W2086834997C55493867 @default.

• next