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- W2086846391 abstract "Sesquicillin, isolated from fungal fermentation broth, strongly induced G1 phase arrest in human breast cancer cells. During G1 phase arrest, the expression level of cyclin D1, cyclin A, and cyclin E was decreased, and the expression of CDK (cyclin-dependent-kinase) inhibitor, protein p21(Waf1/Cip1), was increased in a time-dependent manner in a breast cancer cell MCF-7. Interestingly, the G1 phase arrest induced by sesquicillin also occurred independently of the tumor suppressor protein, p53. Sesquicillin inhibits the proliferation of MCF-7 via G1 phase arrest in association with the induction of CDK inhibitor protein, p21(Waf1/Cip1), and the reduction of G1 phase related-cyclin proteins." @default.
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- W2086846391 date "2002-10-01" @default.
- W2086846391 modified "2023-09-23" @default.
- W2086846391 title "Biological effects of G1 phase arrest compound, sesquicillin, in human breast cancer cell lines" @default.
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- W2086846391 doi "https://doi.org/10.1016/s0968-0896(02)00225-0" @default.
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