FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086857869> ?p ?o ?g. }

• W2086857869 endingPage "108" @default.
• W2086857869 startingPage "104" @default.
• W2086857869 abstract "Objectives: Hemorrhagic shock (HS) can initiate an exaggerated systemic inflammatory response and multiple organ failure, especially if followed by a subsequent inflammatory insult (“second hit”). We have recently shown that histone deacetylase inhibitors can improve survival in rodent models of HS or septic shock, individually. In the present study, we examined whether valproic acid (VPA), a histone deacetylase inhibitor, could prolong survival in a rodent “two-hit” model: HS followed by septic shock from cecal ligation and puncture (CLP). Methods: Male Sprague-Dawley rats (250–300 g) were subjected to sublethal HS (40% blood loss) and then randomly divided into two groups (n = 7/group): VPA and control. The VPA group was treated intraperitoneally with VPA (300 mg/kg in normal saline [NS], volume = 750 μL/kg). The control group was injected with 750 μL/kg NS. After 24 h, all rats received CLP followed immediately by injection of the same dose of VPA (VPA group) or NS (vehicle group). Survival was monitored for 10 days. In a parallel study, serum and peritoneal irrigation fluid from VPA- or vehicle-treated rats were collected 3, 6, and 24 h after CLP, and enzyme-linked immunosorbent assay was performed to analyze myeloperoxidase activity and determine tumor necrosis factor α and interleukin 6 concentrations. Hematoxylin-eosin staining of lungs at 24-h time point was performed to investigate the grade of acute lung injury. Results: Rats treated with VPA (300 mg/kg) showed significantly higher survival rates (85.7%) compared with the control (14.3%). Moreover, VPA significantly suppressed myeloperoxidase activity (marker of neutrophil-mediated oxidative damage) and inhibited levels of proinflammatory cytokine tumor necrosis factor α and interleukin 6 in the serum and peritoneal cavity. Meanwhile, the severity of acute lung injury was significantly reduced in VPA-treated animals. Conclusions: We have demonstrated that VPA treatment improves survival and attenuates inflammation in a rodent two-hit model." @default.
• W2086857869 created "2016-06-24" @default.
• W2086857869 creator A5006052857 @default.
• W2086857869 creator A5012198189 @default.
• W2086857869 creator A5031136904 @default.
• W2086857869 creator A5032642797 @default.
• W2086857869 creator A5038385267 @default.
• W2086857869 creator A5054859377 @default.
• W2086857869 creator A5058961918 @default.
• W2086857869 creator A5060897359 @default.
• W2086857869 creator A5077625963 @default.
• W2086857869 date "2014-02-01" @default.
• W2086857869 modified "2023-10-10" @default.
• W2086857869 title "Creating a Prosurvival Phenotype Through a Histone Deacetylase Inhibitor in a Lethal Two-Hit Model" @default.
• W2086857869 cites W1521883584 @default.
• W2086857869 cites W1963975982 @default.
• W2086857869 cites W1969397460 @default.
• W2086857869 cites W1980654946 @default.
• W2086857869 cites W1985745444 @default.
• W2086857869 cites W2013027490 @default.
• W2086857869 cites W2020187563 @default.
• W2086857869 cites W2023945291 @default.
• W2086857869 cites W2049927822 @default.
• W2086857869 cites W2071934663 @default.
• W2086857869 cites W2073446553 @default.
• W2086857869 cites W2084253055 @default.
• W2086857869 cites W2088217789 @default.
• W2086857869 cites W2090313500 @default.
• W2086857869 cites W2107204307 @default.
• W2086857869 cites W2111430444 @default.
• W2086857869 cites W2112310203 @default.
• W2086857869 cites W2115769793 @default.
• W2086857869 cites W2121683669 @default.
• W2086857869 cites W2125498567 @default.
• W2086857869 cites W2132206417 @default.
• W2086857869 cites W2145447273 @default.
• W2086857869 cites W2153794985 @default.
• W2086857869 doi "https://doi.org/10.1097/shk.0000000000000074" @default.
• W2086857869 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4822203" @default.
• W2086857869 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24430491" @default.
• W2086857869 hasPublicationYear "2014" @default.
• W2086857869 type Work @default.
• W2086857869 sameAs 2086857869 @default.
• W2086857869 citedByCount "32" @default.
• W2086857869 countsByYear W20868578692014 @default.
• W2086857869 countsByYear W20868578692015 @default.
• W2086857869 countsByYear W20868578692016 @default.
• W2086857869 countsByYear W20868578692017 @default.
• W2086857869 countsByYear W20868578692018 @default.
• W2086857869 countsByYear W20868578692019 @default.
• W2086857869 countsByYear W20868578692020 @default.
• W2086857869 countsByYear W20868578692021 @default.
• W2086857869 countsByYear W20868578692023 @default.
• W2086857869 crossrefType "journal-article" @default.
• W2086857869 hasAuthorship W2086857869A5006052857 @default.
• W2086857869 hasAuthorship W2086857869A5012198189 @default.
• W2086857869 hasAuthorship W2086857869A5031136904 @default.
• W2086857869 hasAuthorship W2086857869A5032642797 @default.
• W2086857869 hasAuthorship W2086857869A5038385267 @default.
• W2086857869 hasAuthorship W2086857869A5054859377 @default.
• W2086857869 hasAuthorship W2086857869A5058961918 @default.
• W2086857869 hasAuthorship W2086857869A5060897359 @default.
• W2086857869 hasAuthorship W2086857869A5077625963 @default.
• W2086857869 hasBestOaLocation W20868578691 @default.
• W2086857869 hasConcept C104317684 @default.
• W2086857869 hasConcept C118552586 @default.
• W2086857869 hasConcept C125473707 @default.
• W2086857869 hasConcept C126322002 @default.
• W2086857869 hasConcept C17991360 @default.
• W2086857869 hasConcept C185592680 @default.
• W2086857869 hasConcept C203014093 @default.
• W2086857869 hasConcept C203565725 @default.
• W2086857869 hasConcept C204232928 @default.
• W2086857869 hasConcept C2776202225 @default.
• W2086857869 hasConcept C2776914184 @default.
• W2086857869 hasConcept C2777172819 @default.
• W2086857869 hasConcept C2777397205 @default.
• W2086857869 hasConcept C2777628635 @default.
• W2086857869 hasConcept C2778186239 @default.
• W2086857869 hasConcept C2778305200 @default.
• W2086857869 hasConcept C2778384902 @default.
• W2086857869 hasConcept C55493867 @default.
• W2086857869 hasConcept C64927066 @default.
• W2086857869 hasConcept C71924100 @default.
• W2086857869 hasConcept C98274493 @default.
• W2086857869 hasConceptScore W2086857869C104317684 @default.
• W2086857869 hasConceptScore W2086857869C118552586 @default.
• W2086857869 hasConceptScore W2086857869C125473707 @default.
• W2086857869 hasConceptScore W2086857869C126322002 @default.
• W2086857869 hasConceptScore W2086857869C17991360 @default.
• W2086857869 hasConceptScore W2086857869C185592680 @default.
• W2086857869 hasConceptScore W2086857869C203014093 @default.
• W2086857869 hasConceptScore W2086857869C203565725 @default.
• W2086857869 hasConceptScore W2086857869C204232928 @default.
• W2086857869 hasConceptScore W2086857869C2776202225 @default.
• W2086857869 hasConceptScore W2086857869C2776914184 @default.
• W2086857869 hasConceptScore W2086857869C2777172819 @default.
• W2086857869 hasConceptScore W2086857869C2777397205 @default.

• next