FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086864004> ?p ?o ?g. }

• W2086864004 endingPage "32" @default.
• W2086864004 startingPage "25" @default.
• W2086864004 abstract "CD8+ T cells primed in the absence of CD4+ T cell help are programmed to produce TRAIL, which results in Death receptor (DR5) mediated apoptosis upon restimulation. Here, we studied whether these ‘helpless’ effector CD8+ T cells are consigned to an apoptotic fate or whether their helpless program can be altered by inflammatory or growth cytokines. We found that helpless CD8+ T cells regained their full proliferative and functional capacity only when IL-2 was added to cell cultures, while IL-7 and IL-15, two common gamma chain cytokines associated with CD8+ T cell homeostasis and memory, could only partly restore secondary expansion in helpless CD8+ T cells. Recovery of functional CD8+ T cell immunity by IL-2 was concomitant with induction of IL2Rα (CD25) expression, downregulation of TRAIL, and the upregulation of anti-apoptotic molecules Bcl-2 and FLIP. The addition of IL-2 to helpless CD8+ T cells also interfered with DR5-mediated apoptosis induction, indicating that IL-2 affects several components of the TRAIL-DR5 pathway. Collectively, these data demonstrate that the helpless phenotype is not fixed, and that IL-2R signaling at the time of reactivation can play an important role in restoring CD8+ T cell function." @default.
• W2086864004 created "2016-06-24" @default.
• W2086864004 creator A5014729402 @default.
• W2086864004 creator A5064530526 @default.
• W2086864004 creator A5075655484 @default.
• W2086864004 creator A5085829700 @default.
• W2086864004 creator A5087282255 @default.
• W2086864004 date "2011-09-01" @default.
• W2086864004 modified "2023-09-25" @default.
• W2086864004 title "Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated death" @default.
• W2086864004 cites W1482928030 @default.
• W2086864004 cites W1493822493 @default.
• W2086864004 cites W1507800008 @default.
• W2086864004 cites W1599781349 @default.
• W2086864004 cites W1971902136 @default.
• W2086864004 cites W1975401854 @default.
• W2086864004 cites W1975682095 @default.
• W2086864004 cites W1983918344 @default.
• W2086864004 cites W1986222655 @default.
• W2086864004 cites W1986376227 @default.
• W2086864004 cites W2003959861 @default.
• W2086864004 cites W2005154465 @default.
• W2086864004 cites W2008354811 @default.
• W2086864004 cites W2008511270 @default.
• W2086864004 cites W2008667095 @default.
• W2086864004 cites W2017176455 @default.
• W2086864004 cites W2017669223 @default.
• W2086864004 cites W2041218370 @default.
• W2086864004 cites W2058001723 @default.
• W2086864004 cites W2069340283 @default.
• W2086864004 cites W2076534074 @default.
• W2086864004 cites W2078704491 @default.
• W2086864004 cites W2085583663 @default.
• W2086864004 cites W2095405582 @default.
• W2086864004 cites W2111945592 @default.
• W2086864004 cites W2114683657 @default.
• W2086864004 cites W2146641952 @default.
• W2086864004 cites W2149764521 @default.
• W2086864004 cites W2161888789 @default.
• W2086864004 cites W4313331292 @default.
• W2086864004 doi "https://doi.org/10.1016/j.imlet.2011.04.011" @default.
• W2086864004 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3146632" @default.
• W2086864004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21621553" @default.
• W2086864004 hasPublicationYear "2011" @default.
• W2086864004 type Work @default.
• W2086864004 sameAs 2086864004 @default.
• W2086864004 citedByCount "18" @default.
• W2086864004 countsByYear W20868640042012 @default.
• W2086864004 countsByYear W20868640042013 @default.
• W2086864004 countsByYear W20868640042014 @default.
• W2086864004 countsByYear W20868640042015 @default.
• W2086864004 countsByYear W20868640042016 @default.
• W2086864004 countsByYear W20868640042017 @default.
• W2086864004 countsByYear W20868640042018 @default.
• W2086864004 countsByYear W20868640042019 @default.
• W2086864004 crossrefType "journal-article" @default.
• W2086864004 hasAuthorship W2086864004A5014729402 @default.
• W2086864004 hasAuthorship W2086864004A5064530526 @default.
• W2086864004 hasAuthorship W2086864004A5075655484 @default.
• W2086864004 hasAuthorship W2086864004A5085829700 @default.
• W2086864004 hasAuthorship W2086864004A5087282255 @default.
• W2086864004 hasBestOaLocation W20868640042 @default.
• W2086864004 hasConcept C104317684 @default.
• W2086864004 hasConcept C120642132 @default.
• W2086864004 hasConcept C127561419 @default.
• W2086864004 hasConcept C129374314 @default.
• W2086864004 hasConcept C154317977 @default.
• W2086864004 hasConcept C167672396 @default.
• W2086864004 hasConcept C190283241 @default.
• W2086864004 hasConcept C202751555 @default.
• W2086864004 hasConcept C203014093 @default.
• W2086864004 hasConcept C2776090121 @default.
• W2086864004 hasConcept C2778690821 @default.
• W2086864004 hasConcept C31573885 @default.
• W2086864004 hasConcept C51785407 @default.
• W2086864004 hasConcept C55493867 @default.
• W2086864004 hasConcept C74172505 @default.
• W2086864004 hasConcept C79484868 @default.
• W2086864004 hasConcept C86803240 @default.
• W2086864004 hasConcept C8891405 @default.
• W2086864004 hasConcept C95444343 @default.
• W2086864004 hasConcept C98119934 @default.
• W2086864004 hasConceptScore W2086864004C104317684 @default.
• W2086864004 hasConceptScore W2086864004C120642132 @default.
• W2086864004 hasConceptScore W2086864004C127561419 @default.
• W2086864004 hasConceptScore W2086864004C129374314 @default.
• W2086864004 hasConceptScore W2086864004C154317977 @default.
• W2086864004 hasConceptScore W2086864004C167672396 @default.
• W2086864004 hasConceptScore W2086864004C190283241 @default.
• W2086864004 hasConceptScore W2086864004C202751555 @default.
• W2086864004 hasConceptScore W2086864004C203014093 @default.
• W2086864004 hasConceptScore W2086864004C2776090121 @default.
• W2086864004 hasConceptScore W2086864004C2778690821 @default.
• W2086864004 hasConceptScore W2086864004C31573885 @default.
• W2086864004 hasConceptScore W2086864004C51785407 @default.
• W2086864004 hasConceptScore W2086864004C55493867 @default.
• W2086864004 hasConceptScore W2086864004C74172505 @default.
• W2086864004 hasConceptScore W2086864004C79484868 @default.

• next