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• W2086911518 abstract "HIV-1 Tat protein reprograms cellular gene expression of infected as well as uninfected cells apart from its primary function of transactivating HIV-1 long terminal repeat (LTR) promoter by binding to a nascent RNA stem-loop structure known as the transactivator response region (TAR). Tat also induces chromatin remodeling of proviral LTR-mediated gene expression by recruiting histone acetyl transferases to the chromatin, which results in histone acetylation. Furthermore several studies have shown convincing evidence that Tat can transactivate HIV-1 gene expression in the absence of TAR, the molecular mechanism of which remains to be elucidated. Here we show a direct interaction of Tat with nuclear factor kappa B (NFkappaB) enhancer, a global regulatory sequence for many cellular genes both in vitro and in vivo. This interaction not only provides a novel molecular basis to explain TAR-independent transactivation in HIV-1, but also points toward the potential mechanism of Tat- mediated modulation of cellular genes." @default.
• W2086911518 created "2016-06-24" @default.
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• W2086911518 creator A5046980689 @default.
• W2086911518 creator A5078836870 @default.
• W2086911518 date "2004-02-23" @default.
• W2086911518 modified "2023-09-27" @default.
• W2086911518 title "HIV-1 Tat directly binds to NF B enhancer sequence: role in viral and cellular gene expression" @default.
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• W2086911518 doi "https://doi.org/10.1093/nar/gkh289" @default.
• W2086911518 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/390279" @default.
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• W2086911518 hasPublicationYear "2004" @default.
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