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• W2086922166 endingPage "338" @default.
• W2086922166 startingPage "330" @default.
• W2086922166 abstract "Summary. Background: Platelets play a role in a number of inflammatory conditions including atherosclerosis; however, the mechanisms of platelet activation under these conditions are unclear. Objectives: To investigate the presence of the vanilloid receptor, TRPV1, which is stimulated by noxious stimuli and by inflammatory mediators, in human platelets. Methods: Platelets loaded with fura-2 or sodium-binding benzofuran isophalate acetoxymethyl ester (SBFI) were used to monitor cytosolic calcium or sodium concentrations. 5-HT secretion was determined by fluorescence assay after conjugation with o-phthaldialdehyde. ATP secretion was determined using luciferin-luciferase. Results: TRPV1 was identified by Western blotting using a specific anti-hTRPV1 antibody. The TRPV1 agonist, capsaicin, evoked both Ca2+ influx and Ca2+ release from intracellular stores, responses that were blocked in a dose-dependent manner by the TRPV1 antagonists, 5′-Iodo-resiniferatoxin (5′-Iodo-RTX) and AMG 9810. Capsaicin also increased platelet cytosolic [Na+]. Capsaicin-evoked Ca2+ release was abolished in the absence of extracellular Na+ or by the 5-HT2A receptor antagonist, ketanserin. Capsaicin evoked 5-HT release from platelets, a response abolished in the absence of extracellular Na+ or by 5′-Iodo-RTX. Thus capsaicin-evoked Ca2+ release appeared to be mediated by Na+-dependent 5-HT release. TRPV1-dependent 5-HT release also contributed to ADP- and thrombin-evoked Ca2+ entry and release. 5′-Iodo-RTX reduced ADP- and thrombin-evoked Ca2+ signals, effects not additive with those of ketanserin, and 5′-Iodo-RTX inhibited agonist-evoked 5-HT and ATP release. Conclusion: These results indicate that TRPV1 is present and functionally important in human platelets. The presence of this receptor may provide a link between inflammatory mediators and platelet activation in conditions such as atherosclerosis." @default.
• W2086922166 created "2016-06-24" @default.
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• W2086922166 date "2009-02-01" @default.
• W2086922166 modified "2023-09-26" @default.
• W2086922166 title "A role for TRPV1 in agonist‐evoked activation of human platelets" @default.
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• W2086922166 doi "https://doi.org/10.1111/j.1538-7836.2008.03231.x" @default.
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