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• W2086927107 abstract "The development of cancer is driven by the accumulation of scores of alterations affecting the structure and function of the genome. Equally important in this process are genetic alterations and epigenetic changes. Whereas the former disrupt normal patterns of gene expression, sometimes leading to the expression of abnormal, constitutively active proteins, the latter deregulate the mechanisms such as transcriptional control leading to the inappropriate silencing or activation of cancer-associated genes. Both types of changes are inheritable at the cellular level, thus contributing to the clonal expansion of cancer cells. In this review, we summarize current knowledge on how genetic alterations in oncogenes or tumour suppressor genes, as well as epigenetic changes, can be exploited in the clinics as biomarkers for cancer detection, diagnosis and prognosis. We propose a rationale for identifying alterations that may have a functional impact within a background of passenger alterations that may occur solely as the consequence of deregulated genetic and epigenetic stability. Such functional alterations may represent candidates for targeted therapeutic approaches." @default.
• W2086927107 created "2016-06-24" @default.
• W2086927107 creator A5070367652 @default.
• W2086927107 creator A5083815533 @default.
• W2086927107 date "2007-03-14" @default.
• W2086927107 modified "2023-10-06" @default.
• W2086927107 title "Genetic and epigenetic alterations as biomarkers for cancer detection, diagnosis and prognosis" @default.
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