Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086941398> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2086941398 endingPage "977" @default.
- W2086941398 startingPage "974" @default.
- W2086941398 abstract "Several studies provided evidence of innate interferons (IFNs) regulating T(H)2 cytokine production using purified CD4(+) memory cells and T(H)2 polarisation via interleukin-4 (IL-4). Vitally, none of these previous studies examined IFN attenuation of T(H)2 responses to allergen or antigen. This study therefore sought to investigate the abrogation of specific allergen- and antigen-stimulated T(H)2 response in peripheral blood mononuclear cells (PBMC) derived from 12 sensitised individuals by IFN-β and IFN-λ. PBMC were cultured in the presence of house dust mite (HDM) allergen, rhinovirus (RV), influenza vaccine and tetanus toxoid (TT)±either IFN-β or IFN-λ for 3 and 5 days. IFN-γ, IL-5 and IL-13 protein levels were measured by ELISA. Quantitative PCR (qPCR) was used to investigate induction of genes involved in control of T(H)2 cytokines. No alteration in T(H)1 IFN-γ allergen/antigen response was observed with addition of IFN-β or IFN-λ. Consistent abrogation of T(H)2 response to HDM and influenza was observed with IFN-β at both time points; attenuation was observed by day 5 with RV and TT. IFN-λ had no consistent effect on T(H)2 production except in the presence of RV (multiplicity of infection=5); a decrease in IL-5 alone was observed in the presence of trivalent inactivated influenza vaccine. GATA binding protein 3 (GATA3) and suppressors of cytokine signalling3 mRNA were differentially regulated in HDM and influenza-stimulated cultures±IFN-β. We concluded that IFN-β produced a strong and consistent abrogation of T(H)2 cytokine production in the presence of a range of allergen and antigen stimulants." @default.
- W2086941398 created "2016-06-24" @default.
- W2086941398 creator A5034776323 @default.
- W2086941398 creator A5035806248 @default.
- W2086941398 creator A5068291843 @default.
- W2086941398 creator A5090327971 @default.
- W2086941398 date "2012-07-24" @default.
- W2086941398 modified "2023-09-26" @default.
- W2086941398 title "Innate interferons inhibit allergen and microbial specific T <sub>H</sub> 2 responses" @default.
- W2086941398 cites W1544691147 @default.
- W2086941398 cites W1919378623 @default.
- W2086941398 cites W1958137504 @default.
- W2086941398 cites W1965472353 @default.
- W2086941398 cites W1989698859 @default.
- W2086941398 cites W1997665554 @default.
- W2086941398 cites W2007736853 @default.
- W2086941398 cites W2016160459 @default.
- W2086941398 cites W2022729636 @default.
- W2086941398 cites W2031344413 @default.
- W2086941398 cites W2031769256 @default.
- W2086941398 cites W2060591764 @default.
- W2086941398 cites W2062429849 @default.
- W2086941398 cites W2063145133 @default.
- W2086941398 cites W2093213568 @default.
- W2086941398 cites W2098915990 @default.
- W2086941398 cites W2112433605 @default.
- W2086941398 cites W2135030836 @default.
- W2086941398 cites W2135968732 @default.
- W2086941398 cites W2162545931 @default.
- W2086941398 cites W2171494950 @default.
- W2086941398 cites W2171749467 @default.
- W2086941398 cites W2328746135 @default.
- W2086941398 doi "https://doi.org/10.1038/icb.2012.39" @default.
- W2086941398 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22825591" @default.
- W2086941398 hasPublicationYear "2012" @default.
- W2086941398 type Work @default.
- W2086941398 sameAs 2086941398 @default.
- W2086941398 citedByCount "18" @default.
- W2086941398 countsByYear W20869413982013 @default.
- W2086941398 countsByYear W20869413982014 @default.
- W2086941398 countsByYear W20869413982016 @default.
- W2086941398 countsByYear W20869413982017 @default.
- W2086941398 countsByYear W20869413982019 @default.
- W2086941398 countsByYear W20869413982020 @default.
- W2086941398 countsByYear W20869413982022 @default.
- W2086941398 crossrefType "journal-article" @default.
- W2086941398 hasAuthorship W2086941398A5034776323 @default.
- W2086941398 hasAuthorship W2086941398A5035806248 @default.
- W2086941398 hasAuthorship W2086941398A5068291843 @default.
- W2086941398 hasAuthorship W2086941398A5090327971 @default.
- W2086941398 hasConcept C137061746 @default.
- W2086941398 hasConcept C147483822 @default.
- W2086941398 hasConcept C202751555 @default.
- W2086941398 hasConcept C203014093 @default.
- W2086941398 hasConcept C207480886 @default.
- W2086941398 hasConcept C2776178377 @default.
- W2086941398 hasConcept C2777351567 @default.
- W2086941398 hasConcept C2778166374 @default.
- W2086941398 hasConcept C2778690821 @default.
- W2086941398 hasConcept C2780510475 @default.
- W2086941398 hasConcept C2780801004 @default.
- W2086941398 hasConcept C55493867 @default.
- W2086941398 hasConcept C86803240 @default.
- W2086941398 hasConceptScore W2086941398C137061746 @default.
- W2086941398 hasConceptScore W2086941398C147483822 @default.
- W2086941398 hasConceptScore W2086941398C202751555 @default.
- W2086941398 hasConceptScore W2086941398C203014093 @default.
- W2086941398 hasConceptScore W2086941398C207480886 @default.
- W2086941398 hasConceptScore W2086941398C2776178377 @default.
- W2086941398 hasConceptScore W2086941398C2777351567 @default.
- W2086941398 hasConceptScore W2086941398C2778166374 @default.
- W2086941398 hasConceptScore W2086941398C2778690821 @default.
- W2086941398 hasConceptScore W2086941398C2780510475 @default.
- W2086941398 hasConceptScore W2086941398C2780801004 @default.
- W2086941398 hasConceptScore W2086941398C55493867 @default.
- W2086941398 hasConceptScore W2086941398C86803240 @default.
- W2086941398 hasIssue "10" @default.
- W2086941398 hasLocation W20869413981 @default.
- W2086941398 hasLocation W20869413982 @default.
- W2086941398 hasOpenAccess W2086941398 @default.
- W2086941398 hasPrimaryLocation W20869413981 @default.
- W2086941398 hasRelatedWork W2005843091 @default.
- W2086941398 hasRelatedWork W2036943877 @default.
- W2086941398 hasRelatedWork W2037019085 @default.
- W2086941398 hasRelatedWork W2056313719 @default.
- W2086941398 hasRelatedWork W2059012962 @default.
- W2086941398 hasRelatedWork W2065426285 @default.
- W2086941398 hasRelatedWork W2092683273 @default.
- W2086941398 hasRelatedWork W2106365458 @default.
- W2086941398 hasRelatedWork W2112795145 @default.
- W2086941398 hasRelatedWork W2573502857 @default.
- W2086941398 hasVolume "90" @default.
- W2086941398 isParatext "false" @default.
- W2086941398 isRetracted "false" @default.
- W2086941398 magId "2086941398" @default.
- W2086941398 workType "article" @default.