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- W2086952244 abstract "This paper focuses on novel approaches in the field of nanotechnology-based carriers utilizing ultrasound stimuli as a means to spatially target gene delivery in vivo , using nanoparticles made with either poly(lactic-co-glycolic acid) (PLGA) or other polymers. We specifically discuss the potential for gene delivery by particles that are echogenic (amenable to destruction by ultrasound) composed either of polymers (PLGA, polystyrene) or other contrast agent materials (Optison, SonoVue microbubbles). The use of ultrasound is an efficient tool to further enhance gene delivery by PLGA or other echogenic particles in vivo . Echogenic PLGA nanoparticles are an attractive strategy for ultrasound-mediated gene delivery since this polymer is currently approved by the US Food and Drug Administration for drug delivery and diagnostics in cancer, cardiovascular disease, and also other applications such as vaccines and tissue engineering. This paper will review recent successes and the potential of applying PLGA nanoparticles for gene delivery, which include (a) echogenic PLGA used with ultrasound to enhance local gene delivery in tumors or muscle and (b) PLGA nanoparticles currently under development, which could benefit in the future from ultrasound-enhanced tumor targeted gene delivery." @default.
- W2086952244 created "2016-06-24" @default.
- W2086952244 creator A5019247030 @default.
- W2086952244 creator A5065342039 @default.
- W2086952244 date "2012-02-28" @default.
- W2086952244 modified "2023-10-01" @default.
- W2086952244 title "PLGA Nanoparticles for Ultrasound-Mediated Gene Delivery to Solid Tumors" @default.
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- W2086952244 doi "https://doi.org/10.1155/2012/767839" @default.
- W2086952244 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3312337" @default.
- W2086952244 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22506124" @default.
- W2086952244 hasPublicationYear "2012" @default.
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