FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086953885> ?p ?o ?g. }

• W2086953885 endingPage "454" @default.
• W2086953885 startingPage "449" @default.
• W2086953885 abstract "Given the importance of protein phosphorylation in the context of cellular functions, abnormal protein phosphatase activity has been implicated in several diseases, including cancer. These critical roles of protein phosphatases qualify them as potential targets for the development of medicinal compounds that possess distinct modes of action such as violacein. In this work, studies with this natural indolic pigment at a concentration of 10.0 micromol L(-1) demonstrated a 20% activation of total protein phosphatase extracted from human lymphocytes. Although no alteration was observed on protein tyrosine phosphatase (CD45), 30% of inhibition was achieved in cytoplasmatic protein phosphatase activity after incubation with 10.0 micromol L(-1) violacein. Additionally, 5.0 micromol L(-1) of violacein inhibited by 50% the serum tartrate-resistant acid phosphatase activity. Violacein presented toxic effect on lymphocytes with IC50 values of 3 and 10 micromol L(-1) for protein content and protein phosphatase activity, respectively. These findings suggest an important role for protein phosphatases in the mechanisms controlling proliferation and cell death." @default.
• W2086953885 created "2016-06-24" @default.
• W2086953885 creator A5003100159 @default.
• W2086953885 creator A5008179604 @default.
• W2086953885 creator A5024774400 @default.
• W2086953885 creator A5036853123 @default.
• W2086953885 creator A5072342063 @default.
• W2086953885 date "2005-01-01" @default.
• W2086953885 modified "2023-09-30" @default.
• W2086953885 title "Violacein cytotoxicity on human blood lymphocytes and effect on phosphatases" @default.
• W2086953885 cites W155788393 @default.
• W2086953885 cites W1629179716 @default.
• W2086953885 cites W1934912969 @default.
• W2086953885 cites W1972514324 @default.
• W2086953885 cites W1973819128 @default.
• W2086953885 cites W1974825648 @default.
• W2086953885 cites W2005193114 @default.
• W2086953885 cites W2011767881 @default.
• W2086953885 cites W2014281089 @default.
• W2086953885 cites W2023961347 @default.
• W2086953885 cites W2024727248 @default.
• W2086953885 cites W2025143050 @default.
• W2086953885 cites W2032588409 @default.
• W2086953885 cites W2043854033 @default.
• W2086953885 cites W2048621842 @default.
• W2086953885 cites W2060286683 @default.
• W2086953885 cites W2066451762 @default.
• W2086953885 cites W2071613269 @default.
• W2086953885 cites W2084775369 @default.
• W2086953885 cites W2091231741 @default.
• W2086953885 cites W2093010544 @default.
• W2086953885 cites W2114829464 @default.
• W2086953885 cites W2114918609 @default.
• W2086953885 cites W2137080510 @default.
• W2086953885 cites W2142229422 @default.
• W2086953885 cites W2142944050 @default.
• W2086953885 cites W2152277794 @default.
• W2086953885 cites W2153115688 @default.
• W2086953885 cites W2159620177 @default.
• W2086953885 cites W2911486466 @default.
• W2086953885 cites W2952925491 @default.
• W2086953885 doi "https://doi.org/10.1080/14756360500273052" @default.
• W2086953885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16335052" @default.
• W2086953885 hasPublicationYear "2005" @default.
• W2086953885 type Work @default.
• W2086953885 sameAs 2086953885 @default.
• W2086953885 citedByCount "27" @default.
• W2086953885 countsByYear W20869538852012 @default.
• W2086953885 countsByYear W20869538852013 @default.
• W2086953885 countsByYear W20869538852014 @default.
• W2086953885 countsByYear W20869538852015 @default.
• W2086953885 countsByYear W20869538852016 @default.
• W2086953885 countsByYear W20869538852017 @default.
• W2086953885 countsByYear W20869538852021 @default.
• W2086953885 countsByYear W20869538852023 @default.
• W2086953885 crossrefType "journal-article" @default.
• W2086953885 hasAuthorship W2086953885A5003100159 @default.
• W2086953885 hasAuthorship W2086953885A5008179604 @default.
• W2086953885 hasAuthorship W2086953885A5024774400 @default.
• W2086953885 hasAuthorship W2086953885A5036853123 @default.
• W2086953885 hasAuthorship W2086953885A5072342063 @default.
• W2086953885 hasConcept C109316439 @default.
• W2086953885 hasConcept C11960822 @default.
• W2086953885 hasConcept C151730666 @default.
• W2086953885 hasConcept C178666793 @default.
• W2086953885 hasConcept C181199279 @default.
• W2086953885 hasConcept C185592680 @default.
• W2086953885 hasConcept C202751555 @default.
• W2086953885 hasConcept C21547065 @default.
• W2086953885 hasConcept C2779343474 @default.
• W2086953885 hasConcept C389152 @default.
• W2086953885 hasConcept C55493867 @default.
• W2086953885 hasConcept C85528070 @default.
• W2086953885 hasConcept C86803240 @default.
• W2086953885 hasConcept C97920573 @default.
• W2086953885 hasConceptScore W2086953885C109316439 @default.
• W2086953885 hasConceptScore W2086953885C11960822 @default.
• W2086953885 hasConceptScore W2086953885C151730666 @default.
• W2086953885 hasConceptScore W2086953885C178666793 @default.
• W2086953885 hasConceptScore W2086953885C181199279 @default.
• W2086953885 hasConceptScore W2086953885C185592680 @default.
• W2086953885 hasConceptScore W2086953885C202751555 @default.
• W2086953885 hasConceptScore W2086953885C21547065 @default.
• W2086953885 hasConceptScore W2086953885C2779343474 @default.
• W2086953885 hasConceptScore W2086953885C389152 @default.
• W2086953885 hasConceptScore W2086953885C55493867 @default.
• W2086953885 hasConceptScore W2086953885C85528070 @default.
• W2086953885 hasConceptScore W2086953885C86803240 @default.
• W2086953885 hasConceptScore W2086953885C97920573 @default.
• W2086953885 hasIssue "5" @default.
• W2086953885 hasLocation W20869538851 @default.
• W2086953885 hasLocation W20869538852 @default.
• W2086953885 hasOpenAccess W2086953885 @default.
• W2086953885 hasPrimaryLocation W20869538851 @default.
• W2086953885 hasRelatedWork W104091829 @default.
• W2086953885 hasRelatedWork W1986604108 @default.
• W2086953885 hasRelatedWork W1988275566 @default.
• W2086953885 hasRelatedWork W2061404727 @default.

• next