Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086967717> ?p ?o ?g. }
- W2086967717 endingPage "1726" @default.
- W2086967717 startingPage "1709" @default.
- W2086967717 abstract "Pterostilbene and 3,5-hydroxypterostilbene are the natural 3,5-dimethoxy analogs of trans-resveratrol and piceatannol, two compounds which can induce apoptosis in tumor cells. In previous studies we demonstrated the importance of a 3,5-dimethoxy motif in conferring pro-apoptotic activity to stilbene based compounds so we now wanted to evaluate the ability of pterostilbene and 3,5-hydroxypterostilbene in inducing apoptosis in sensitive and resistant leukemia cells. When tested in sensitive cell lines, HL60 and HUT78, 3'-hydroxypterostilbene was 50-97 times more potent than trans-resveratrol in inducing apoptosis, while pterostilbene appeared barely active. However, both compounds, but not trans-resveratrol and piceatannol, were able to induce apoptosis in the two Fas-ligand resistant lymphoma cell lines, HUT78B1 and HUT78B3, and the multi drug-resistant leukemia cell lines HL60-R and K562-ADR (a Bcr-Abl-expressing cell line resistant to imatinib mesylate). Of note, pterostilbene-induced apoptosis was not inhibited by the pancaspase-inhibitor Z-VAD-fmk, suggesting that this compound acts through a caspase-independent pathway. On the contrary, 3'-hydroxypterostilbene seemed to trigger apoptosis through the intrinsic apoptotic pathway: indeed, it caused a marked disruption of the mitochondrial membrane potential delta psi and its apoptotic effects were inhibited by Z-VAD-fmk and the caspase-9-inhibitor Z-LEHD-fmk. Moreover, pterostilbene and 3'-hydroxypterostilbene, when used at concentrations that elicit significant apoptotic effects in tumor cell lines, did not show any cytotoxicity in normal hemopoietic stem cells. In conclusion, our data show that pterostilbene and particularly 3'-hydroxypterostilbene are interesting antitumor natural compounds that may be useful in the treatment of resistant hematological malignancies, including imatinib, non-responsive neoplasms." @default.
- W2086967717 created "2016-06-24" @default.
- W2086967717 creator A5001882547 @default.
- W2086967717 creator A5010189561 @default.
- W2086967717 creator A5020949961 @default.
- W2086967717 creator A5023544659 @default.
- W2086967717 creator A5044783285 @default.
- W2086967717 creator A5045620495 @default.
- W2086967717 creator A5046088110 @default.
- W2086967717 creator A5050289046 @default.
- W2086967717 creator A5054586779 @default.
- W2086967717 creator A5056212782 @default.
- W2086967717 creator A5064088704 @default.
- W2086967717 creator A5070625007 @default.
- W2086967717 creator A5082949748 @default.
- W2086967717 creator A5091471093 @default.
- W2086967717 date "2005-08-01" @default.
- W2086967717 modified "2023-09-27" @default.
- W2086967717 title "Pterostilbene and 3′-hydroxypterostilbene are effective apoptosis-inducing agents in MDR and BCR-ABL-expressing leukemia cells" @default.
- W2086967717 cites W157402533 @default.
- W2086967717 cites W1764225789 @default.
- W2086967717 cites W1772617136 @default.
- W2086967717 cites W1898126039 @default.
- W2086967717 cites W1963846930 @default.
- W2086967717 cites W1971034764 @default.
- W2086967717 cites W1977252276 @default.
- W2086967717 cites W1979501382 @default.
- W2086967717 cites W1986776963 @default.
- W2086967717 cites W1994114133 @default.
- W2086967717 cites W1996721832 @default.
- W2086967717 cites W1997951817 @default.
- W2086967717 cites W2012077091 @default.
- W2086967717 cites W2025041127 @default.
- W2086967717 cites W2026145799 @default.
- W2086967717 cites W2028889221 @default.
- W2086967717 cites W2037231157 @default.
- W2086967717 cites W2039191003 @default.
- W2086967717 cites W2063726085 @default.
- W2086967717 cites W2067350317 @default.
- W2086967717 cites W2081525633 @default.
- W2086967717 cites W2098785293 @default.
- W2086967717 cites W2119369177 @default.
- W2086967717 cites W2119898601 @default.
- W2086967717 cites W2125947878 @default.
- W2086967717 cites W2126655188 @default.
- W2086967717 cites W2142851289 @default.
- W2086967717 cites W2149726552 @default.
- W2086967717 cites W2151089147 @default.
- W2086967717 cites W2158034359 @default.
- W2086967717 cites W2159503225 @default.
- W2086967717 cites W2166185936 @default.
- W2086967717 cites W2227735896 @default.
- W2086967717 cites W2316662277 @default.
- W2086967717 cites W2323953269 @default.
- W2086967717 cites W2335526988 @default.
- W2086967717 cites W262406365 @default.
- W2086967717 cites W3113125785 @default.
- W2086967717 cites W4236884242 @default.
- W2086967717 doi "https://doi.org/10.1016/j.biocel.2005.03.004" @default.
- W2086967717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15878840" @default.
- W2086967717 hasPublicationYear "2005" @default.
- W2086967717 type Work @default.
- W2086967717 sameAs 2086967717 @default.
- W2086967717 citedByCount "146" @default.
- W2086967717 countsByYear W20869677172012 @default.
- W2086967717 countsByYear W20869677172013 @default.
- W2086967717 countsByYear W20869677172014 @default.
- W2086967717 countsByYear W20869677172015 @default.
- W2086967717 countsByYear W20869677172016 @default.
- W2086967717 countsByYear W20869677172017 @default.
- W2086967717 countsByYear W20869677172018 @default.
- W2086967717 countsByYear W20869677172019 @default.
- W2086967717 countsByYear W20869677172020 @default.
- W2086967717 countsByYear W20869677172021 @default.
- W2086967717 countsByYear W20869677172022 @default.
- W2086967717 countsByYear W20869677172023 @default.
- W2086967717 crossrefType "journal-article" @default.
- W2086967717 hasAuthorship W2086967717A5001882547 @default.
- W2086967717 hasAuthorship W2086967717A5010189561 @default.
- W2086967717 hasAuthorship W2086967717A5020949961 @default.
- W2086967717 hasAuthorship W2086967717A5023544659 @default.
- W2086967717 hasAuthorship W2086967717A5044783285 @default.
- W2086967717 hasAuthorship W2086967717A5045620495 @default.
- W2086967717 hasAuthorship W2086967717A5046088110 @default.
- W2086967717 hasAuthorship W2086967717A5050289046 @default.
- W2086967717 hasAuthorship W2086967717A5054586779 @default.
- W2086967717 hasAuthorship W2086967717A5056212782 @default.
- W2086967717 hasAuthorship W2086967717A5064088704 @default.
- W2086967717 hasAuthorship W2086967717A5070625007 @default.
- W2086967717 hasAuthorship W2086967717A5082949748 @default.
- W2086967717 hasAuthorship W2086967717A5091471093 @default.
- W2086967717 hasConcept C179464577 @default.
- W2086967717 hasConcept C185592680 @default.
- W2086967717 hasConcept C190283241 @default.
- W2086967717 hasConcept C203014093 @default.
- W2086967717 hasConcept C2776090121 @default.
- W2086967717 hasConcept C2776816829 @default.
- W2086967717 hasConcept C2778461978 @default.