Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086976851> ?p ?o ?g. }
- W2086976851 endingPage "119" @default.
- W2086976851 startingPage "113" @default.
- W2086976851 abstract "Mastoparan is an α-helical and amphipathic tetradecapeptide obtained from the venom of the wasp Vespula lewisii. This peptide exhibits a wide variety of biological effects, including antimicrobial activity, increased histamine release from mast cells, induction of a potent mitochondrial permeability transition and tumor cell cytotoxicity. Here, the effects of mastoparan in malignant melanoma were studied using the murine model of B16F10-Nex2 cells. In vitro, mastoparan caused melanoma cell death by the mitochondrial apoptosis pathway, as evidenced by the Annexin V-FITC/PI assay, loss of mitochondrial membrane potential (ΔΨm), generation of reactive oxygen species, DNA degradation and cell death signaling. Most importantly, mastoparan reduced the growth of subcutaneous melanoma in syngeneic mice and increased their survival. The present results show that mastoparan induced caspase-dependent apoptosis in melanoma cells through the intrinsic mitochondrial pathway protecting the mice against tumor development." @default.
- W2086976851 created "2016-06-24" @default.
- W2086976851 creator A5003935492 @default.
- W2086976851 creator A5007726999 @default.
- W2086976851 creator A5010135765 @default.
- W2086976851 creator A5022436732 @default.
- W2086976851 creator A5024170031 @default.
- W2086976851 creator A5024902792 @default.
- W2086976851 creator A5028688606 @default.
- W2086976851 creator A5031352542 @default.
- W2086976851 creator A5036050822 @default.
- W2086976851 creator A5047861181 @default.
- W2086976851 creator A5051107142 @default.
- W2086976851 creator A5054381064 @default.
- W2086976851 creator A5068768246 @default.
- W2086976851 creator A5069038549 @default.
- W2086976851 creator A5071573571 @default.
- W2086976851 creator A5075975485 @default.
- W2086976851 date "2015-06-01" @default.
- W2086976851 modified "2023-10-01" @default.
- W2086976851 title "Mastoparan induces apoptosis in B16F10-Nex2 melanoma cells via the intrinsic mitochondrial pathway and displays antitumor activity in vivo" @default.
- W2086976851 cites W1876742335 @default.
- W2086976851 cites W1952406478 @default.
- W2086976851 cites W1980100638 @default.
- W2086976851 cites W1986568749 @default.
- W2086976851 cites W1993238109 @default.
- W2086976851 cites W2008757142 @default.
- W2086976851 cites W2009068601 @default.
- W2086976851 cites W2012706912 @default.
- W2086976851 cites W2014164252 @default.
- W2086976851 cites W2026036357 @default.
- W2086976851 cites W2027328852 @default.
- W2086976851 cites W2033408660 @default.
- W2086976851 cites W2038803714 @default.
- W2086976851 cites W2041992938 @default.
- W2086976851 cites W2043435873 @default.
- W2086976851 cites W2045563337 @default.
- W2086976851 cites W2049418180 @default.
- W2086976851 cites W2050413417 @default.
- W2086976851 cites W2052663697 @default.
- W2086976851 cites W2055478604 @default.
- W2086976851 cites W2056961821 @default.
- W2086976851 cites W2057536036 @default.
- W2086976851 cites W2061260890 @default.
- W2086976851 cites W2072569792 @default.
- W2086976851 cites W2086552730 @default.
- W2086976851 cites W2087485038 @default.
- W2086976851 cites W2100756870 @default.
- W2086976851 cites W2123250752 @default.
- W2086976851 cites W2138360960 @default.
- W2086976851 cites W2145694409 @default.
- W2086976851 cites W2152369326 @default.
- W2086976851 cites W2152793164 @default.
- W2086976851 cites W2158730778 @default.
- W2086976851 cites W2163670039 @default.
- W2086976851 cites W2168310850 @default.
- W2086976851 cites W2171525424 @default.
- W2086976851 cites W2298727698 @default.
- W2086976851 cites W2316680848 @default.
- W2086976851 cites W4211123988 @default.
- W2086976851 doi "https://doi.org/10.1016/j.peptides.2014.09.024" @default.
- W2086976851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25305549" @default.
- W2086976851 hasPublicationYear "2015" @default.
- W2086976851 type Work @default.
- W2086976851 sameAs 2086976851 @default.
- W2086976851 citedByCount "49" @default.
- W2086976851 countsByYear W20869768512015 @default.
- W2086976851 countsByYear W20869768512016 @default.
- W2086976851 countsByYear W20869768512017 @default.
- W2086976851 countsByYear W20869768512018 @default.
- W2086976851 countsByYear W20869768512019 @default.
- W2086976851 countsByYear W20869768512020 @default.
- W2086976851 countsByYear W20869768512021 @default.
- W2086976851 countsByYear W20869768512022 @default.
- W2086976851 countsByYear W20869768512023 @default.
- W2086976851 crossrefType "journal-article" @default.
- W2086976851 hasAuthorship W2086976851A5003935492 @default.
- W2086976851 hasAuthorship W2086976851A5007726999 @default.
- W2086976851 hasAuthorship W2086976851A5010135765 @default.
- W2086976851 hasAuthorship W2086976851A5022436732 @default.
- W2086976851 hasAuthorship W2086976851A5024170031 @default.
- W2086976851 hasAuthorship W2086976851A5024902792 @default.
- W2086976851 hasAuthorship W2086976851A5028688606 @default.
- W2086976851 hasAuthorship W2086976851A5031352542 @default.
- W2086976851 hasAuthorship W2086976851A5036050822 @default.
- W2086976851 hasAuthorship W2086976851A5047861181 @default.
- W2086976851 hasAuthorship W2086976851A5051107142 @default.
- W2086976851 hasAuthorship W2086976851A5054381064 @default.
- W2086976851 hasAuthorship W2086976851A5068768246 @default.
- W2086976851 hasAuthorship W2086976851A5069038549 @default.
- W2086976851 hasAuthorship W2086976851A5071573571 @default.
- W2086976851 hasAuthorship W2086976851A5075975485 @default.
- W2086976851 hasConcept C109316439 @default.
- W2086976851 hasConcept C13591479 @default.
- W2086976851 hasConcept C153911025 @default.
- W2086976851 hasConcept C190283241 @default.
- W2086976851 hasConcept C202751555 @default.
- W2086976851 hasConcept C2777658100 @default.