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• W2086978839 abstract "X-ray irradiation influences metastatic properties of tumor cells and, moreover, metastasis and cellular motility can be modified by members of the Eph receptor/ephrin family of receptor tyrosine kinases. We hypothesized that irradiation-induced changes in cellular properties relevant for metastasis in melanoma cells could be mediated by Eph receptor/ephrin signaling. In this pilot study, we analyzed one pre-metastatic (Mel-Juso) and three metastatic human melanoma (Mel-Juso-L3, A375, and A2058) cells lines and predominantly found anti-metastatic effects of X-ray irradiation with impaired cell growth, clonal growth and motility. Additionally, we observed an irradiation-induced increase in adhesion paralleled by a decrease in migration in Mel-Juso and Mel-Juso-L3 cells and, in part, also in A375 cells. We further demonstrate a decrease of EphA2 both in expression and activity at 7 d after irradiation paralleled by an upregulation of EphA3. Analyzing downstream signaling after irradiation, we detected decreased Src kinase phosphorylation, but unchanged focal adhesion kinase (FAK) phosphorylation, indicating, in part, irradiation-induced downregulation of signaling via the EphA2-Src-FAK axis in melanoma cells. However, to which extent this finding contributes to the modification of metastasis-relevant cellular properties remains to be elucidated." @default.
• W2086978839 created "2016-06-24" @default.
• W2086978839 creator A5038541945 @default.
• W2086978839 creator A5086741053 @default.
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• W2086978839 date "2012-03-01" @default.
• W2086978839 modified "2023-09-25" @default.
• W2086978839 title "Irradiation affects cellular properties and Eph receptor expression in human melanoma cells" @default.
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• W2086978839 doi "https://doi.org/10.4161/cam.20655" @default.
• W2086978839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3499310" @default.
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