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- W2086978872 abstract "The mechanisms of Fc receptor blocking by anti-Ig, anti-Ia, and anti-B2 microglobulin (anti-B2Mi) antibodies were compared on human peripheral blood mononuclear cells. The results suggest that Fc receptors were “co-endocytosed” with sIg/anti-Ig and la/anti-Ia complexes, while they were “co-shed” with B2Mi/anti-B2Mi complexes during the incubation with the antibodies at 37 °C. Fc receptors recovered after the blocking by anti-B2Mi or anti-Ig, but not after anti-Ia or heat-aggregated human IgG(Agg Hg) treatment. Lymphocytes were able to replace their endocytosed or shed Fc receptors presumably from a preformed cytoplasmic receptor pool. Anti-Ia antibodies and AggHg probably exhausted this Fc receptor pool or inhibited its transport to the membrane causing an irreversible inhibition of Fc receptor expression on the appropriate cells." @default.
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- W2086978872 date "1980-12-01" @default.
- W2086978872 modified "2023-09-29" @default.
- W2086978872 title "The involvement of a preformed cytoplasmic receptor pool in the reexpression of Fc receptors following their interaction with various antibodies" @default.
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- W2086978872 doi "https://doi.org/10.1016/0008-8749(80)90120-3" @default.
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