FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086983721> ?p ?o ?g. }

• W2086983721 endingPage "5611" @default.
• W2086983721 startingPage "5601" @default.
• W2086983721 abstract "Abstract While the classification of diffuse gliomas has relied on the examination of morphologic features supplemented with techniques such as immunohistochemistry, there is an increasing recognition of substantial biologic diversity within morphologically defined entities. High-throughput technologies, in particular studies that integrate genome-wide data from diverse molecular platforms, increasingly identify the existence of robust and distinct glioma subtypes. While treatment advances and improvement of outcomes for patients with diffuse glioma have been modest, there may be benefit to integrate findings from biologic studies into clinical practice to enhance the precision of treatment for these diseases. Recent examples such as the identification of mutations in IDH1 and IDH2 as an early genetic event that is predominantly in lower-grade gliomas (grades 2 and 3) underscore the importance of molecular discovery leading to the ability to develop subclassifications with prognostic and potentially therapeutic implications. In contrast, glioblastoma (grade 4), the most common and aggressive glioma, typically arises without IDH mutation, supporting the need for different therapeutic approaches. Additional genomic and epigenomic signatures are generally nonoverlapping between IDH-mutant and IDH wild-type diffuse glioma, and despite comparable histopathology, IDH-mutant gliomas can be considered as biologically distinct from IDH wild-type gliomas. In this CCR Focus article, we highlight and summarize the current understanding of recent molecular findings and the relationships of these findings to clinical trials and clinical management. See all articles in this CCR Focus section, “Discoveries, Challenges, and Progress in Primary Brain Tumors.” Clin Cancer Res; 20(22); 5601–11. ©2014 AACR." @default.
• W2086983721 created "2016-06-24" @default.
• W2086983721 creator A5024476694 @default.
• W2086983721 creator A5063290790 @default.
• W2086983721 date "2014-11-13" @default.
• W2086983721 modified "2023-09-26" @default.
• W2086983721 title "The Evolving Role of Molecular Markers in the Diagnosis and Management of Diffuse Glioma" @default.
• W2086983721 cites W1530069278 @default.
• W2086983721 cites W1921809757 @default.
• W2086983721 cites W1969217042 @default.
• W2086983721 cites W1970174108 @default.
• W2086983721 cites W1977116102 @default.
• W2086983721 cites W1980500001 @default.
• W2086983721 cites W1983841375 @default.
• W2086983721 cites W1983922487 @default.
• W2086983721 cites W1984513377 @default.
• W2086983721 cites W1985115576 @default.
• W2086983721 cites W1986009297 @default.
• W2086983721 cites W1988756388 @default.
• W2086983721 cites W1989891384 @default.
• W2086983721 cites W1991862374 @default.
• W2086983721 cites W1993427232 @default.
• W2086983721 cites W2001493754 @default.
• W2086983721 cites W2009149174 @default.
• W2086983721 cites W2011097571 @default.
• W2086983721 cites W2021678893 @default.
• W2086983721 cites W2022064821 @default.
• W2086983721 cites W2022401242 @default.
• W2086983721 cites W2024672608 @default.
• W2086983721 cites W2025183726 @default.
• W2086983721 cites W2028701963 @default.
• W2086983721 cites W2030017878 @default.
• W2086983721 cites W2030964595 @default.
• W2086983721 cites W2035021866 @default.
• W2086983721 cites W2036044314 @default.
• W2086983721 cites W2036117141 @default.
• W2086983721 cites W2038796494 @default.
• W2086983721 cites W2039872271 @default.
• W2086983721 cites W2040827479 @default.
• W2086983721 cites W2061760261 @default.
• W2086983721 cites W2080452140 @default.
• W2086983721 cites W2080664885 @default.
• W2086983721 cites W2092618575 @default.
• W2086983721 cites W2096287682 @default.
• W2086983721 cites W2096681571 @default.
• W2086983721 cites W2104683360 @default.
• W2086983721 cites W2105100844 @default.
• W2086983721 cites W2105526612 @default.
• W2086983721 cites W2105528101 @default.
• W2086983721 cites W2107731988 @default.
• W2086983721 cites W2108854209 @default.
• W2086983721 cites W2113613085 @default.
• W2086983721 cites W2113729674 @default.
• W2086983721 cites W2113942802 @default.
• W2086983721 cites W2115276344 @default.
• W2086983721 cites W2117521607 @default.
• W2086983721 cites W2120872266 @default.
• W2086983721 cites W2123295392 @default.
• W2086983721 cites W2125556118 @default.
• W2086983721 cites W2127901599 @default.
• W2086983721 cites W2130511906 @default.
• W2086983721 cites W2131117209 @default.
• W2086983721 cites W2131403504 @default.
• W2086983721 cites W2133865472 @default.
• W2086983721 cites W2137189485 @default.
• W2086983721 cites W2140417249 @default.
• W2086983721 cites W2141713919 @default.
• W2086983721 cites W2142630775 @default.
• W2086983721 cites W2144242568 @default.
• W2086983721 cites W2145755261 @default.
• W2086983721 cites W2147013683 @default.
• W2086983721 cites W2149576862 @default.
• W2086983721 cites W2151311897 @default.
• W2086983721 cites W2151336775 @default.
• W2086983721 cites W2154526619 @default.
• W2086983721 cites W2160102037 @default.
• W2086983721 cites W2160382843 @default.
• W2086983721 cites W2161289668 @default.
• W2086983721 cites W2163325084 @default.
• W2086983721 cites W2164459955 @default.
• W2086983721 cites W2171078630 @default.
• W2086983721 cites W2171418517 @default.
• W2086983721 cites W2328946792 @default.
• W2086983721 doi "https://doi.org/10.1158/1078-0432.ccr-14-0831" @default.
• W2086983721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25398843" @default.
• W2086983721 hasPublicationYear "2014" @default.
• W2086983721 type Work @default.
• W2086983721 sameAs 2086983721 @default.
• W2086983721 citedByCount "47" @default.
• W2086983721 countsByYear W20869837212014 @default.
• W2086983721 countsByYear W20869837212015 @default.
• W2086983721 countsByYear W20869837212016 @default.
• W2086983721 countsByYear W20869837212017 @default.
• W2086983721 countsByYear W20869837212018 @default.
• W2086983721 countsByYear W20869837212019 @default.
• W2086983721 countsByYear W20869837212020 @default.
• W2086983721 countsByYear W20869837212021 @default.
• W2086983721 countsByYear W20869837212022 @default.

• next