FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086996025> ?p ?o ?g. }

• W2086996025 endingPage "276" @default.
• W2086996025 startingPage "266" @default.
• W2086996025 abstract "The aim of this study was to evaluate the effect and molecular mechanism of albumin infusion on cardiac contractility in experimental cirrhosis with ascites. Cardiac contractility was recorded ex vivo in rats with cirrhosis and ascites and in control rats after the injection in the caudal vein of albumin, saline, or hydroxyethyl starch (HES). Gene and protein expression of β-receptors and pathways involved in their intracellular signaling such as Gα(i2) protein (Gα(i2)), adenylate cyclase 3 (Adcy3), protein expression of tumor necrosis factor alpha (TNF-α) and inducible nitric oxide synthase (iNOS), were evaluated in cardiac tissue in both groups. Phosphorylation and membrane-translocation of the cytosolic components of nicotinamide adenine dinucleotide phosphate (NAD(P)H)-oxidase and translocation of nuclear factor kappa B (NF-κB) were also evaluated. After saline intravenous injection, cardiac contractility was significantly reduced in rats with cirrhosis as compared to control rats (P < 0.01). This was associated with: (1) increased expression of protein Gα(i2) (P < 0.05), TNF-α (P < 0.05), iNOS (P < 0.05); (2) increased NAD(P)H-oxidase activity (P < 0.05); (3) increased nuclear translocation of NF-κB (P < 0.05); and (4) lower expression of Adcy 3 (P < 0.05) in cardiac tissue of rats with cirrhosis. After albumin injection cardiac contractility (P < 0.01), protein expression of TNF-α, iNOS, Gα(i2), and Adcy3, NAD(P)H-oxidase activity and nuclear translocation of NF-κB in cardiac tissue of rats with cirrhosis were reversed to control levels (P < 0.05). HES injection did not modify cardiac contractility and nuclear translocation of NF-κB in cardiac tissue of rats with cirrhosis.Albumin exerts a positive cardiac inotropic effect in rats with cirrhosis and ascites counteracting the negative effects of oxidative stress- and TNF-α-induced activation of NF-κB-iNOS pathway and oxidative stress-induced alteration of β-receptor signaling." @default.
• W2086996025 created "2016-06-24" @default.
• W2086996025 creator A5003122029 @default.
• W2086996025 creator A5003339887 @default.
• W2086996025 creator A5006387483 @default.
• W2086996025 creator A5007434584 @default.
• W2086996025 creator A5026789895 @default.
• W2086996025 creator A5057012887 @default.
• W2086996025 creator A5065210915 @default.
• W2086996025 creator A5069130616 @default.
• W2086996025 creator A5069554705 @default.
• W2086996025 creator A5076347297 @default.
• W2086996025 creator A5090984249 @default.
• W2086996025 date "2013-01-01" @default.
• W2086996025 modified "2023-10-16" @default.
• W2086996025 title "Positive cardiac inotropic effect of albumin infusion in rodents with cirrhosis and ascites: molecular mechanisms" @default.
• W2086996025 cites W1228830179 @default.
• W2086996025 cites W1970075023 @default.
• W2086996025 cites W1992098105 @default.
• W2086996025 cites W1997948095 @default.
• W2086996025 cites W2003475514 @default.
• W2086996025 cites W2016687768 @default.
• W2086996025 cites W2019408416 @default.
• W2086996025 cites W2020899877 @default.
• W2086996025 cites W2056677038 @default.
• W2086996025 cites W2079742453 @default.
• W2086996025 cites W2081317807 @default.
• W2086996025 cites W2084830964 @default.
• W2086996025 cites W2087502638 @default.
• W2086996025 cites W2094023852 @default.
• W2086996025 cites W2100582442 @default.
• W2086996025 cites W2106455193 @default.
• W2086996025 cites W2113830114 @default.
• W2086996025 cites W2115591084 @default.
• W2086996025 cites W2121846817 @default.
• W2086996025 cites W2136928735 @default.
• W2086996025 cites W2138354938 @default.
• W2086996025 cites W2139424224 @default.
• W2086996025 cites W2152356908 @default.
• W2086996025 cites W2163857743 @default.
• W2086996025 cites W2322673970 @default.
• W2086996025 cites W2783716685 @default.
• W2086996025 cites W4210712363 @default.
• W2086996025 cites W4233656649 @default.
• W2086996025 doi "https://doi.org/10.1002/hep.26021" @default.
• W2086996025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22911662" @default.
• W2086996025 hasPublicationYear "2013" @default.
• W2086996025 type Work @default.
• W2086996025 sameAs 2086996025 @default.
• W2086996025 citedByCount "100" @default.
• W2086996025 countsByYear W20869960252013 @default.
• W2086996025 countsByYear W20869960252014 @default.
• W2086996025 countsByYear W20869960252015 @default.
• W2086996025 countsByYear W20869960252016 @default.
• W2086996025 countsByYear W20869960252017 @default.
• W2086996025 countsByYear W20869960252018 @default.
• W2086996025 countsByYear W20869960252019 @default.
• W2086996025 countsByYear W20869960252020 @default.
• W2086996025 countsByYear W20869960252021 @default.
• W2086996025 countsByYear W20869960252022 @default.
• W2086996025 countsByYear W20869960252023 @default.
• W2086996025 crossrefType "journal-article" @default.
• W2086996025 hasAuthorship W2086996025A5003122029 @default.
• W2086996025 hasAuthorship W2086996025A5003339887 @default.
• W2086996025 hasAuthorship W2086996025A5006387483 @default.
• W2086996025 hasAuthorship W2086996025A5007434584 @default.
• W2086996025 hasAuthorship W2086996025A5026789895 @default.
• W2086996025 hasAuthorship W2086996025A5057012887 @default.
• W2086996025 hasAuthorship W2086996025A5065210915 @default.
• W2086996025 hasAuthorship W2086996025A5069130616 @default.
• W2086996025 hasAuthorship W2086996025A5069554705 @default.
• W2086996025 hasAuthorship W2086996025A5076347297 @default.
• W2086996025 hasAuthorship W2086996025A5090984249 @default.
• W2086996025 hasBestOaLocation W20869960251 @default.
• W2086996025 hasConcept C126322002 @default.
• W2086996025 hasConcept C134018914 @default.
• W2086996025 hasConcept C181199279 @default.
• W2086996025 hasConcept C185592680 @default.
• W2086996025 hasConcept C2777214474 @default.
• W2086996025 hasConcept C2777989768 @default.
• W2086996025 hasConcept C38485361 @default.
• W2086996025 hasConcept C39133596 @default.
• W2086996025 hasConcept C55493867 @default.
• W2086996025 hasConcept C71924100 @default.
• W2086996025 hasConcept C75520062 @default.
• W2086996025 hasConcept C86803240 @default.
• W2086996025 hasConceptScore W2086996025C126322002 @default.
• W2086996025 hasConceptScore W2086996025C134018914 @default.
• W2086996025 hasConceptScore W2086996025C181199279 @default.
• W2086996025 hasConceptScore W2086996025C185592680 @default.
• W2086996025 hasConceptScore W2086996025C2777214474 @default.
• W2086996025 hasConceptScore W2086996025C2777989768 @default.
• W2086996025 hasConceptScore W2086996025C38485361 @default.
• W2086996025 hasConceptScore W2086996025C39133596 @default.
• W2086996025 hasConceptScore W2086996025C55493867 @default.
• W2086996025 hasConceptScore W2086996025C71924100 @default.
• W2086996025 hasConceptScore W2086996025C75520062 @default.
• W2086996025 hasConceptScore W2086996025C86803240 @default.

• next