Matches in SemOpenAlex for { <https://semopenalex.org/work/W2086996888> ?p ?o ?g. }
- W2086996888 endingPage "420" @default.
- W2086996888 startingPage "411" @default.
- W2086996888 abstract "Nervous system development is reliant on neuronal pathfinding, the process in which axons are guided to their target cells by specific extracellular cues. The ability of neurons to extend over long distances in response to environmental guidance signals is made possible by the growth cone, a highly motile structure found at the end of neuronal processes. Growth cones detect directional cues and respond with either attractive or repulsive movements. The motility of growth cones is dependent on rapid reorganization of the actin cytoskeleton, presumably mediated by actin-associated proteins under the control of incoming guidance signals. This article reviews how one such family of proteins, the ADF/cofilins, are emerging as key regulators of growth cone actin dynamics. These proteins are essential for rapid actin turnover in a variety of different cell types. ADF/cofilins are heavily co-localized with actin in growth cones and are necessary for neurite outgrowth. ADF/cofilin activities are regulated through reversible phosphorylation by LIM kinases and slingshot phosphatases. LIM kinases are downstream effectors of the Rho GTPases Rho, Rac, and Cdc42. Growing evidence suggests that extracellular guidance cues may locally alter actin dynamics by regulating the activity of LIM kinase and ADF/cofilin phosphatases via the Rho GTPases. In this way, ADF/cofilins and their upstream effectors may be pivotal to our understanding of how guidance information is translated into physical alterations of the growth cone actin cytoskeleton." @default.
- W2086996888 created "2016-06-24" @default.
- W2086996888 creator A5088598466 @default.
- W2086996888 creator A5089167961 @default.
- W2086996888 date "2003-04-01" @default.
- W2086996888 modified "2023-10-15" @default.
- W2086996888 title "Regulation of Growth Cone Actin Dynamics by ADF/Cofilin" @default.
- W2086996888 cites W1484094963 @default.
- W2086996888 cites W1488423107 @default.
- W2086996888 cites W1490646520 @default.
- W2086996888 cites W1498142612 @default.
- W2086996888 cites W1508695192 @default.
- W2086996888 cites W1522015108 @default.
- W2086996888 cites W1543719249 @default.
- W2086996888 cites W1582832269 @default.
- W2086996888 cites W1589135618 @default.
- W2086996888 cites W1593617603 @default.
- W2086996888 cites W1626096776 @default.
- W2086996888 cites W1640813462 @default.
- W2086996888 cites W1646460047 @default.
- W2086996888 cites W1833899379 @default.
- W2086996888 cites W1964993651 @default.
- W2086996888 cites W1967203969 @default.
- W2086996888 cites W1970195231 @default.
- W2086996888 cites W1984030342 @default.
- W2086996888 cites W1989642116 @default.
- W2086996888 cites W1991345297 @default.
- W2086996888 cites W1991878174 @default.
- W2086996888 cites W1992557615 @default.
- W2086996888 cites W1992835639 @default.
- W2086996888 cites W1995340790 @default.
- W2086996888 cites W1995757732 @default.
- W2086996888 cites W1996002116 @default.
- W2086996888 cites W2002003879 @default.
- W2086996888 cites W2003084435 @default.
- W2086996888 cites W2003736664 @default.
- W2086996888 cites W2006591827 @default.
- W2086996888 cites W2007586038 @default.
- W2086996888 cites W2007660746 @default.
- W2086996888 cites W2008038351 @default.
- W2086996888 cites W2010147661 @default.
- W2086996888 cites W2011756230 @default.
- W2086996888 cites W2018317768 @default.
- W2086996888 cites W2024171558 @default.
- W2086996888 cites W2026856916 @default.
- W2086996888 cites W2027126201 @default.
- W2086996888 cites W2027810531 @default.
- W2086996888 cites W2028363992 @default.
- W2086996888 cites W2028939491 @default.
- W2086996888 cites W2030486608 @default.
- W2086996888 cites W2034466289 @default.
- W2086996888 cites W2035339007 @default.
- W2086996888 cites W2039723960 @default.
- W2086996888 cites W2053431375 @default.
- W2086996888 cites W2057864153 @default.
- W2086996888 cites W2058246130 @default.
- W2086996888 cites W2063963676 @default.
- W2086996888 cites W2069482812 @default.
- W2086996888 cites W2072706075 @default.
- W2086996888 cites W2072938810 @default.
- W2086996888 cites W2073368157 @default.
- W2086996888 cites W2074322379 @default.
- W2086996888 cites W2075227275 @default.
- W2086996888 cites W2076848103 @default.
- W2086996888 cites W2090217559 @default.
- W2086996888 cites W2093196157 @default.
- W2086996888 cites W2093226717 @default.
- W2086996888 cites W2093279875 @default.
- W2086996888 cites W2093598851 @default.
- W2086996888 cites W2102666800 @default.
- W2086996888 cites W2105789974 @default.
- W2086996888 cites W2113395636 @default.
- W2086996888 cites W2120613121 @default.
- W2086996888 cites W2122121550 @default.
- W2086996888 cites W2123761308 @default.
- W2086996888 cites W2124248841 @default.
- W2086996888 cites W2124436876 @default.
- W2086996888 cites W2126546276 @default.
- W2086996888 cites W2128535856 @default.
- W2086996888 cites W2130196728 @default.
- W2086996888 cites W2131832714 @default.
- W2086996888 cites W2132837096 @default.
- W2086996888 cites W2137861623 @default.
- W2086996888 cites W2151678953 @default.
- W2086996888 cites W2157815908 @default.
- W2086996888 cites W2160834780 @default.
- W2086996888 cites W2160910785 @default.
- W2086996888 cites W216372990 @default.
- W2086996888 cites W2167146326 @default.
- W2086996888 cites W2167663030 @default.
- W2086996888 cites W2169622416 @default.
- W2086996888 cites W2171395330 @default.
- W2086996888 cites W4213299463 @default.
- W2086996888 doi "https://doi.org/10.1177/002215540305100402" @default.
- W2086996888 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12642619" @default.
- W2086996888 hasPublicationYear "2003" @default.
- W2086996888 type Work @default.
- W2086996888 sameAs 2086996888 @default.