FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087015057> ?p ?o ?g. }

• W2087015057 abstract "In this work, the metabolism of adenosine by isolated BLM associated-enzymes and the implications of this process for the cAMP-signaling pathway are investigated. Inosine was identified as the major metabolic product, suggesting the presence of adenosine deaminase (ADA) activity in the BLM. This was confirmed by immunoblotting and ADA-specific enzyme assay. Implications for the enzymatic deamination of adenosine on the receptor-modulated cAMP-signaling pathway were also investigated. We observed that inosine induced a 2-fold increase in [(35)S] GTPgammaS binding to the BLM and it was inhibited by 10(-6)M DPCPX, an A(1) receptor-selective antagonist. Inosine (10(-7)M) inhibited protein kinase A activity in a DPCPX-sensitive manner. Molecular association between ADA and G(alphai-3) protein-coupled A(1) receptor was demonstrated by co-immunoprecipitation assay. These data show that adenosine is deaminated by A(1) receptor-associated ADA to inosine, which in turn modulates PKA in the BLM through A(1) receptor-mediated inhibition of adenylyl cyclase." @default.
• W2087015057 created "2016-06-24" @default.
• W2087015057 creator A5036426194 @default.
• W2087015057 creator A5045671057 @default.
• W2087015057 creator A5048938088 @default.
• W2087015057 creator A5058786567 @default.
• W2087015057 creator A5069812154 @default.
• W2087015057 creator A5071651947 @default.
• W2087015057 creator A5023872294 @default.
• W2087015057 date "2009-06-01" @default.
• W2087015057 modified "2023-10-18" @default.
• W2087015057 title "Adenosine deamination to inosine in isolated basolateral membrane from kidney proximal tubule: Implications for modulation of the membrane-associated protein kinase A" @default.
• W2087015057 cites W1501063278 @default.
• W2087015057 cites W1524116933 @default.
• W2087015057 cites W1589135378 @default.
• W2087015057 cites W1946525928 @default.
• W2087015057 cites W1965554200 @default.
• W2087015057 cites W1972659352 @default.
• W2087015057 cites W1976150146 @default.
• W2087015057 cites W1978002877 @default.
• W2087015057 cites W1978288233 @default.
• W2087015057 cites W1988475029 @default.
• W2087015057 cites W1989197835 @default.
• W2087015057 cites W1996466550 @default.
• W2087015057 cites W2013538946 @default.
• W2087015057 cites W2023885376 @default.
• W2087015057 cites W2028495886 @default.
• W2087015057 cites W2031233656 @default.
• W2087015057 cites W2043086735 @default.
• W2087015057 cites W2044063604 @default.
• W2087015057 cites W2056966569 @default.
• W2087015057 cites W2069523155 @default.
• W2087015057 cites W2074531755 @default.
• W2087015057 cites W2076223618 @default.
• W2087015057 cites W2079438182 @default.
• W2087015057 cites W2100837269 @default.
• W2087015057 cites W2108988197 @default.
• W2087015057 cites W2111037672 @default.
• W2087015057 cites W2112492912 @default.
• W2087015057 cites W2133580420 @default.
• W2087015057 cites W2141395410 @default.
• W2087015057 cites W2149669670 @default.
• W2087015057 cites W2174534121 @default.
• W2087015057 cites W2330409913 @default.
• W2087015057 doi "https://doi.org/10.1016/j.abb.2009.03.008" @default.
• W2087015057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19327339" @default.
• W2087015057 hasPublicationYear "2009" @default.
• W2087015057 type Work @default.
• W2087015057 sameAs 2087015057 @default.
• W2087015057 citedByCount "5" @default.
• W2087015057 countsByYear W20870150572013 @default.
• W2087015057 crossrefType "journal-article" @default.
• W2087015057 hasAuthorship W2087015057A5023872294 @default.
• W2087015057 hasAuthorship W2087015057A5036426194 @default.
• W2087015057 hasAuthorship W2087015057A5045671057 @default.
• W2087015057 hasAuthorship W2087015057A5048938088 @default.
• W2087015057 hasAuthorship W2087015057A5058786567 @default.
• W2087015057 hasAuthorship W2087015057A5069812154 @default.
• W2087015057 hasAuthorship W2087015057A5071651947 @default.
• W2087015057 hasBestOaLocation W20870150571 @default.
• W2087015057 hasConcept C145782189 @default.
• W2087015057 hasConcept C153911025 @default.
• W2087015057 hasConcept C158424129 @default.
• W2087015057 hasConcept C16587737 @default.
• W2087015057 hasConcept C170493617 @default.
• W2087015057 hasConcept C172590197 @default.
• W2087015057 hasConcept C181199279 @default.
• W2087015057 hasConcept C182683403 @default.
• W2087015057 hasConcept C185592680 @default.
• W2087015057 hasConcept C2776991684 @default.
• W2087015057 hasConcept C2777610669 @default.
• W2087015057 hasConcept C2778938600 @default.
• W2087015057 hasConcept C2779178603 @default.
• W2087015057 hasConcept C2780634109 @default.
• W2087015057 hasConcept C34628245 @default.
• W2087015057 hasConcept C55493867 @default.
• W2087015057 hasConcept C67907053 @default.
• W2087015057 hasConcept C86803240 @default.
• W2087015057 hasConceptScore W2087015057C145782189 @default.
• W2087015057 hasConceptScore W2087015057C153911025 @default.
• W2087015057 hasConceptScore W2087015057C158424129 @default.
• W2087015057 hasConceptScore W2087015057C16587737 @default.
• W2087015057 hasConceptScore W2087015057C170493617 @default.
• W2087015057 hasConceptScore W2087015057C172590197 @default.
• W2087015057 hasConceptScore W2087015057C181199279 @default.
• W2087015057 hasConceptScore W2087015057C182683403 @default.
• W2087015057 hasConceptScore W2087015057C185592680 @default.
• W2087015057 hasConceptScore W2087015057C2776991684 @default.
• W2087015057 hasConceptScore W2087015057C2777610669 @default.
• W2087015057 hasConceptScore W2087015057C2778938600 @default.
• W2087015057 hasConceptScore W2087015057C2779178603 @default.
• W2087015057 hasConceptScore W2087015057C2780634109 @default.
• W2087015057 hasConceptScore W2087015057C34628245 @default.
• W2087015057 hasConceptScore W2087015057C55493867 @default.
• W2087015057 hasConceptScore W2087015057C67907053 @default.
• W2087015057 hasConceptScore W2087015057C86803240 @default.
• W2087015057 hasLocation W20870150571 @default.
• W2087015057 hasLocation W20870150572 @default.
• W2087015057 hasOpenAccess W2087015057 @default.
• W2087015057 hasPrimaryLocation W20870150571 @default.

• next