Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087020611> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2087020611 endingPage "427" @default.
- W2087020611 startingPage "421" @default.
- W2087020611 abstract "Cholesterol homeostasis is strictly maintained to prevent abnormal biological processes that arise from excessive accumulation of cholesterol in tissues. Although dyslipidemia causes reproductive dysfunction and endocrine disruption in male rats, regulatory factors and mechanisms have not been clearly demonstrated. Therefore, the present study investigated the histology of male reproductive organs and the expression of prostatic acid phosphatase (also known as Acpp) that is secreted by cuboidal epithelium of the prostate gland in response to a normal diet and a high-cholesterol diet. The high cholesterol diet increased total cholesterol and low density lipoprotein (LDL) levels and decreased high density lipoprotein (HDL) levels. Histological analyses showed considerable alterations in the prostate indicating excessive papillary projections within the acinar lumen in response to the high cholesterol diet. In addition, Acpp expression was decreased in the penis of rats fed the high cholesterol diet and it was predominantly localized in the urethral epithelium and penile follicle that is precursor of penile spines. Moreover, Acpp was reduced slightly in the testes, but differential expression of Acpp in the prostate in response to dietary cholesterol was not detected. Furthermore, target microRNAs (miRs) of Acpp such as miR-192 and miR-215 regulated Acpp gene expression at the post-transcriptional levels by binding to specific sites within its 3′-UTR. These results indicate that Acpp plays an important role in growth and development of the penis of rats, and its expression is modulated at epigenomic levels via specific miRs." @default.
- W2087020611 created "2016-06-24" @default.
- W2087020611 creator A5023193570 @default.
- W2087020611 creator A5023474900 @default.
- W2087020611 creator A5043922204 @default.
- W2087020611 creator A5046819938 @default.
- W2087020611 creator A5071058729 @default.
- W2087020611 creator A5082211784 @default.
- W2087020611 date "2015-01-01" @default.
- W2087020611 modified "2023-09-26" @default.
- W2087020611 title "Dietary cholesterol affects expression of prostatic acid phosphatase in reproductive organs of male rats" @default.
- W2087020611 cites W1590545381 @default.
- W2087020611 cites W1961818598 @default.
- W2087020611 cites W1972880831 @default.
- W2087020611 cites W1973914400 @default.
- W2087020611 cites W1989189148 @default.
- W2087020611 cites W2009138009 @default.
- W2087020611 cites W2012757292 @default.
- W2087020611 cites W2014393189 @default.
- W2087020611 cites W2017354784 @default.
- W2087020611 cites W2025576517 @default.
- W2087020611 cites W2029586295 @default.
- W2087020611 cites W2030354790 @default.
- W2087020611 cites W2031769175 @default.
- W2087020611 cites W2054796530 @default.
- W2087020611 cites W2066000490 @default.
- W2087020611 cites W2066171157 @default.
- W2087020611 cites W2075728036 @default.
- W2087020611 cites W2079096694 @default.
- W2087020611 cites W2084454944 @default.
- W2087020611 cites W2084803300 @default.
- W2087020611 cites W2089216636 @default.
- W2087020611 cites W2095278176 @default.
- W2087020611 cites W2099040516 @default.
- W2087020611 cites W2100543864 @default.
- W2087020611 cites W2103154123 @default.
- W2087020611 cites W2117658058 @default.
- W2087020611 cites W2129998916 @default.
- W2087020611 cites W2135586734 @default.
- W2087020611 cites W2146864851 @default.
- W2087020611 cites W2161497959 @default.
- W2087020611 cites W2300506 @default.
- W2087020611 cites W4252021281 @default.
- W2087020611 doi "https://doi.org/10.1016/j.bbrc.2014.11.100" @default.
- W2087020611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25482440" @default.
- W2087020611 hasPublicationYear "2015" @default.
- W2087020611 type Work @default.
- W2087020611 sameAs 2087020611 @default.
- W2087020611 citedByCount "6" @default.
- W2087020611 countsByYear W20870206112016 @default.
- W2087020611 countsByYear W20870206112020 @default.
- W2087020611 countsByYear W20870206112021 @default.
- W2087020611 countsByYear W20870206112023 @default.
- W2087020611 crossrefType "journal-article" @default.
- W2087020611 hasAuthorship W2087020611A5023193570 @default.
- W2087020611 hasAuthorship W2087020611A5023474900 @default.
- W2087020611 hasAuthorship W2087020611A5043922204 @default.
- W2087020611 hasAuthorship W2087020611A5046819938 @default.
- W2087020611 hasAuthorship W2087020611A5071058729 @default.
- W2087020611 hasAuthorship W2087020611A5082211784 @default.
- W2087020611 hasConcept C121608353 @default.
- W2087020611 hasConcept C126322002 @default.
- W2087020611 hasConcept C134018914 @default.
- W2087020611 hasConcept C2776235491 @default.
- W2087020611 hasConcept C2776490512 @default.
- W2087020611 hasConcept C2778163477 @default.
- W2087020611 hasConcept C2780541478 @default.
- W2087020611 hasConcept C71924100 @default.
- W2087020611 hasConcept C86803240 @default.
- W2087020611 hasConceptScore W2087020611C121608353 @default.
- W2087020611 hasConceptScore W2087020611C126322002 @default.
- W2087020611 hasConceptScore W2087020611C134018914 @default.
- W2087020611 hasConceptScore W2087020611C2776235491 @default.
- W2087020611 hasConceptScore W2087020611C2776490512 @default.
- W2087020611 hasConceptScore W2087020611C2778163477 @default.
- W2087020611 hasConceptScore W2087020611C2780541478 @default.
- W2087020611 hasConceptScore W2087020611C71924100 @default.
- W2087020611 hasConceptScore W2087020611C86803240 @default.
- W2087020611 hasIssue "1" @default.
- W2087020611 hasLocation W20870206111 @default.
- W2087020611 hasLocation W20870206112 @default.
- W2087020611 hasOpenAccess W2087020611 @default.
- W2087020611 hasPrimaryLocation W20870206111 @default.
- W2087020611 hasRelatedWork W1976602105 @default.
- W2087020611 hasRelatedWork W1998394120 @default.
- W2087020611 hasRelatedWork W2035331946 @default.
- W2087020611 hasRelatedWork W2072909849 @default.
- W2087020611 hasRelatedWork W2090060155 @default.
- W2087020611 hasRelatedWork W2091105399 @default.
- W2087020611 hasRelatedWork W2118738696 @default.
- W2087020611 hasRelatedWork W2157219243 @default.
- W2087020611 hasRelatedWork W2413861530 @default.
- W2087020611 hasRelatedWork W4244653511 @default.
- W2087020611 hasVolume "456" @default.
- W2087020611 isParatext "false" @default.
- W2087020611 isRetracted "false" @default.
- W2087020611 magId "2087020611" @default.
- W2087020611 workType "article" @default.