FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087029192> ?p ?o ?g. }

• W2087029192 endingPage "557" @default.
• W2087029192 startingPage "547" @default.
• W2087029192 abstract "While cannabinoid receptors activate multiple signaling pathways in the brain, it remains unclear what influence the inhibition of adenylylcyclase has on the inhibition of glutamate release. In cerebrocortical nerve terminals, the cannabinoid receptor agonist WIN55,212-2 reduced KCl-evoked glutamate release through a mechanism that restricted the rise of cytoplasmic free Ca2+, but not the changes in plasma membrane depolarization. These effects were consistent with the inhibition of Ca2+ channels. Furthermore, WIN55,212-2 reduced 4-aminopyridine (4AP) evoked glutamate release to a larger extent by modulating the behavior of both Ca2+ and K(+)-channels. The inhibition of 4AP-evoked release was associated with a decrease in cytoplasmic free Ca2+ and in plasma membrane depolarization that was reverted by the potassium channel blocker, tetraethylammonium. Interestingly, the reduction of KCl- and 4AP-evoked release by WIN55,212-2 was independent of adenylylcyclase activity and did not affect cAMP. Forskolin and the beta-adrenergic receptor increase intrasynaptosomal cAMP and promote a PKA-dependent tetrodotoxin (TTX)-sensitive increase in the spontaneous release of glutamate. These two responses were reduced by WIN55,212-2. However, the glutamate release induced by Sp-8-Br-cAMPS, which directly activated PKA without affecting cAMP, was also similarly reduced by WIN55,212-2. Hence, we conclude that the inhibition of glutamate release by WIN55,212-2 is unrelated to changes in cAMP and that the inhibition of release that a decrease in cAMP might produce is occluded by the activation of additional pathways such as the inhibition of Ca2+ channels and/or the activation of K(+)-channels that strongly depress glutamate release." @default.
• W2087029192 created "2016-06-24" @default.
• W2087029192 creator A5004575240 @default.
• W2087029192 creator A5005571724 @default.
• W2087029192 creator A5039184287 @default.
• W2087029192 date "2005-03-01" @default.
• W2087029192 modified "2023-10-02" @default.
• W2087029192 title "The modulation of Ca2+ and K+ channels but not changes in cAMP signaling contribute to the inhibition of glutamate release by cannabinoid receptors in cerebrocortical nerve terminals" @default.
• W2087029192 cites W1498539355 @default.
• W2087029192 cites W1511820456 @default.
• W2087029192 cites W1545631641 @default.
• W2087029192 cites W1670633125 @default.
• W2087029192 cites W1949541784 @default.
• W2087029192 cites W1968870564 @default.
• W2087029192 cites W1968911801 @default.
• W2087029192 cites W1973408906 @default.
• W2087029192 cites W1989756472 @default.
• W2087029192 cites W1994259569 @default.
• W2087029192 cites W2017723141 @default.
• W2087029192 cites W2018953051 @default.
• W2087029192 cites W2030451380 @default.
• W2087029192 cites W2044022880 @default.
• W2087029192 cites W2050455272 @default.
• W2087029192 cites W2052969380 @default.
• W2087029192 cites W2054250221 @default.
• W2087029192 cites W2060694966 @default.
• W2087029192 cites W2064128689 @default.
• W2087029192 cites W2069246118 @default.
• W2087029192 cites W2075918262 @default.
• W2087029192 cites W2079785767 @default.
• W2087029192 cites W2081620736 @default.
• W2087029192 cites W2086369628 @default.
• W2087029192 cites W2096370936 @default.
• W2087029192 cites W2102067199 @default.
• W2087029192 cites W2128810077 @default.
• W2087029192 cites W2137184526 @default.
• W2087029192 cites W2141260882 @default.
• W2087029192 cites W2146478436 @default.
• W2087029192 cites W2165224523 @default.
• W2087029192 cites W2272316754 @default.
• W2087029192 doi "https://doi.org/10.1016/j.neuropharm.2004.11.012" @default.
• W2087029192 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15755482" @default.
• W2087029192 hasPublicationYear "2005" @default.
• W2087029192 type Work @default.
• W2087029192 sameAs 2087029192 @default.
• W2087029192 citedByCount "12" @default.
• W2087029192 countsByYear W20870291922012 @default.
• W2087029192 countsByYear W20870291922013 @default.
• W2087029192 countsByYear W20870291922014 @default.
• W2087029192 crossrefType "journal-article" @default.
• W2087029192 hasAuthorship W2087029192A5004575240 @default.
• W2087029192 hasAuthorship W2087029192A5005571724 @default.
• W2087029192 hasAuthorship W2087029192A5039184287 @default.
• W2087029192 hasConcept C12554922 @default.
• W2087029192 hasConcept C153461711 @default.
• W2087029192 hasConcept C170493617 @default.
• W2087029192 hasConcept C178790620 @default.
• W2087029192 hasConcept C185592680 @default.
• W2087029192 hasConcept C2778938600 @default.
• W2087029192 hasConcept C2779276759 @default.
• W2087029192 hasConcept C4141045 @default.
• W2087029192 hasConcept C519063684 @default.
• W2087029192 hasConcept C55493867 @default.
• W2087029192 hasConcept C61174792 @default.
• W2087029192 hasConcept C67018056 @default.
• W2087029192 hasConcept C83743174 @default.
• W2087029192 hasConcept C86803240 @default.
• W2087029192 hasConcept C98274493 @default.
• W2087029192 hasConceptScore W2087029192C12554922 @default.
• W2087029192 hasConceptScore W2087029192C153461711 @default.
• W2087029192 hasConceptScore W2087029192C170493617 @default.
• W2087029192 hasConceptScore W2087029192C178790620 @default.
• W2087029192 hasConceptScore W2087029192C185592680 @default.
• W2087029192 hasConceptScore W2087029192C2778938600 @default.
• W2087029192 hasConceptScore W2087029192C2779276759 @default.
• W2087029192 hasConceptScore W2087029192C4141045 @default.
• W2087029192 hasConceptScore W2087029192C519063684 @default.
• W2087029192 hasConceptScore W2087029192C55493867 @default.
• W2087029192 hasConceptScore W2087029192C61174792 @default.
• W2087029192 hasConceptScore W2087029192C67018056 @default.
• W2087029192 hasConceptScore W2087029192C83743174 @default.
• W2087029192 hasConceptScore W2087029192C86803240 @default.
• W2087029192 hasConceptScore W2087029192C98274493 @default.
• W2087029192 hasIssue "4" @default.
• W2087029192 hasLocation W20870291921 @default.
• W2087029192 hasLocation W20870291922 @default.
• W2087029192 hasOpenAccess W2087029192 @default.
• W2087029192 hasPrimaryLocation W20870291921 @default.
• W2087029192 hasRelatedWork W2014905699 @default.
• W2087029192 hasRelatedWork W2022920350 @default.
• W2087029192 hasRelatedWork W2035740225 @default.
• W2087029192 hasRelatedWork W2065636160 @default.
• W2087029192 hasRelatedWork W2074333948 @default.
• W2087029192 hasRelatedWork W2168822735 @default.
• W2087029192 hasRelatedWork W2278516098 @default.
• W2087029192 hasRelatedWork W2407270826 @default.
• W2087029192 hasRelatedWork W30654155 @default.
• W2087029192 hasRelatedWork W352646 @default.

• next