Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087029706> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2087029706 endingPage "307" @default.
- W2087029706 startingPage "293" @default.
- W2087029706 abstract "Abstract The biochemical properties of drugs currently used in the clinical treatment of rheumatism and chronic inflammatory disease are examined and it is concluded that: (1) They are polyvalent (able to inhibit several diverse enzyme reactions). (2) At the molecular level, the steroid drugs may act in a rather different manner from the acidic drugs (phenulbutazone, indomethacin, fenamic acids) although the net result of steroid interaction with key events in inflammation may resemble the effects of the acidic drugs in many respects. (3) They can suppress the formation of inflammatory mediators, notably histamine, 5-hydroxytryptamine and perhaps the kinins, and moderate the action of inflammatory proteases. (4) They can deprive inflamed tissue of essential metabolic energy, in the form of adenosine triphosphate (ATP), needed to promote the inflammatory response. (5) The acidic drugs, steroids, and indoxole may affect protein and RNA synthesis in circulating lymphocytes—cells which mediate the immune response and play a role in the pathogenesis of certain chronic inflammatory (and autoimmune?) states. Some molecular determinants of drug activity are discussed briefly." @default.
- W2087029706 created "2016-06-24" @default.
- W2087029706 creator A5046412851 @default.
- W2087029706 date "1968-03-01" @default.
- W2087029706 modified "2023-09-27" @default.
- W2087029706 title "The molecular pharmacology of anti-inflammatory drugs: Some possible mechanisms of action at the biochemical level" @default.
- W2087029706 cites W1247756600 @default.
- W2087029706 cites W1432093581 @default.
- W2087029706 cites W1510564422 @default.
- W2087029706 cites W1514087839 @default.
- W2087029706 cites W1541728265 @default.
- W2087029706 cites W1552143443 @default.
- W2087029706 cites W1562541320 @default.
- W2087029706 cites W1973965062 @default.
- W2087029706 cites W1980907843 @default.
- W2087029706 cites W1981617679 @default.
- W2087029706 cites W1982897285 @default.
- W2087029706 cites W1984572952 @default.
- W2087029706 cites W2002364633 @default.
- W2087029706 cites W2006684546 @default.
- W2087029706 cites W2016718596 @default.
- W2087029706 cites W2030192811 @default.
- W2087029706 cites W2037306774 @default.
- W2087029706 cites W2048192349 @default.
- W2087029706 cites W2049010528 @default.
- W2087029706 cites W2050738854 @default.
- W2087029706 cites W2059523717 @default.
- W2087029706 cites W2064200873 @default.
- W2087029706 cites W2064327752 @default.
- W2087029706 cites W2068874653 @default.
- W2087029706 cites W2076230362 @default.
- W2087029706 cites W2089721470 @default.
- W2087029706 cites W2147055526 @default.
- W2087029706 cites W2155453516 @default.
- W2087029706 cites W2165501281 @default.
- W2087029706 cites W2408923519 @default.
- W2087029706 cites W2552318961 @default.
- W2087029706 cites W4251902175 @default.
- W2087029706 cites W4255707694 @default.
- W2087029706 doi "https://doi.org/10.1016/0006-2952(68)90315-8" @default.
- W2087029706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4968064" @default.
- W2087029706 hasPublicationYear "1968" @default.
- W2087029706 type Work @default.
- W2087029706 sameAs 2087029706 @default.
- W2087029706 citedByCount "26" @default.
- W2087029706 countsByYear W20870297062014 @default.
- W2087029706 crossrefType "journal-article" @default.
- W2087029706 hasAuthorship W2087029706A5046412851 @default.
- W2087029706 hasConcept C121332964 @default.
- W2087029706 hasConcept C14314382 @default.
- W2087029706 hasConcept C170493617 @default.
- W2087029706 hasConcept C185592680 @default.
- W2087029706 hasConcept C202751555 @default.
- W2087029706 hasConcept C2776120743 @default.
- W2087029706 hasConcept C2780791683 @default.
- W2087029706 hasConcept C55493867 @default.
- W2087029706 hasConcept C62520636 @default.
- W2087029706 hasConcept C71924100 @default.
- W2087029706 hasConcept C98274493 @default.
- W2087029706 hasConceptScore W2087029706C121332964 @default.
- W2087029706 hasConceptScore W2087029706C14314382 @default.
- W2087029706 hasConceptScore W2087029706C170493617 @default.
- W2087029706 hasConceptScore W2087029706C185592680 @default.
- W2087029706 hasConceptScore W2087029706C202751555 @default.
- W2087029706 hasConceptScore W2087029706C2776120743 @default.
- W2087029706 hasConceptScore W2087029706C2780791683 @default.
- W2087029706 hasConceptScore W2087029706C55493867 @default.
- W2087029706 hasConceptScore W2087029706C62520636 @default.
- W2087029706 hasConceptScore W2087029706C71924100 @default.
- W2087029706 hasConceptScore W2087029706C98274493 @default.
- W2087029706 hasLocation W20870297061 @default.
- W2087029706 hasLocation W20870297062 @default.
- W2087029706 hasOpenAccess W2087029706 @default.
- W2087029706 hasPrimaryLocation W20870297061 @default.
- W2087029706 hasRelatedWork W2018762970 @default.
- W2087029706 hasRelatedWork W2087029706 @default.
- W2087029706 hasRelatedWork W2165175712 @default.
- W2087029706 hasRelatedWork W2406743770 @default.
- W2087029706 hasRelatedWork W2418534559 @default.
- W2087029706 hasRelatedWork W2429956430 @default.
- W2087029706 hasRelatedWork W2437264929 @default.
- W2087029706 hasRelatedWork W2748952813 @default.
- W2087029706 hasRelatedWork W2899084033 @default.
- W2087029706 hasRelatedWork W418329602 @default.
- W2087029706 hasVolume "17" @default.
- W2087029706 isParatext "false" @default.
- W2087029706 isRetracted "false" @default.
- W2087029706 magId "2087029706" @default.
- W2087029706 workType "article" @default.