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- W2087029768 abstract "MicroRNA-449a (miR-449a) was significantly downregulated in 156 lung cancer tissues (p < 0.001). We found that the low expression of miR-449a was highly correlated with cancer recurrence and survival of lung cancer patients. The transient introduction of miR-449a caused cell cycle arrest and cell senescence in A549 and 95D cells. Further studies revealed that E2F3 was a direct target of miR-449a in lung cancer cells. miR-449a also suppressed tumor formation in vivo in nude mice. These results suggest that miR-449a plays an important role in lung cancer tumorigenesis and that miR-449a might predict cancer recurrence and survival of lung cancer patients." @default.
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- W2087029768 date "2014-03-01" @default.
- W2087029768 modified "2023-10-07" @default.
- W2087029768 title "Tumor-suppressive microRNA-449a induces growth arrest and senescence by targeting E2F3 in human lung cancer cells" @default.
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- W2087029768 doi "https://doi.org/10.1016/j.canlet.2013.10.031" @default.
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