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• W2087041160 abstract "Technologies to assess the molecular targets of biomolecules in living cells are lacking. We have developed a technology called magnetism-based interaction capture (MAGIC) that identifies molecular targets on the basis of induced movement of superparamagnetic nanoparticles inside living cells. Efficient intracellular uptake of superparamagnetic nanoparticles (coated with a small molecule of interest) was mediated by a transducible fusogenic peptide. These nanoprobes captured the small molecule's labeled target protein and were translocated in a direction specified by the magnetic field. Use of MAGIC in genome-wide expression screening identified multiple protein targets of a drug. MAGIC was also used to monitor signal-dependent modification and multiple interactions of proteins." @default.
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• W2087041160 date "2005-07-01" @default.
• W2087041160 modified "2023-10-10" @default.
• W2087041160 title "A Magnetic Nanoprobe Technology for Detecting Molecular Interactions in Live Cells" @default.
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• W2087041160 doi "https://doi.org/10.1126/science.1112869" @default.
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