FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2087044564> ?p ?o ?g. }

• W2087044564 endingPage "1681" @default.
• W2087044564 startingPage "1677" @default.
• W2087044564 abstract "Chromaffin cells were isolated from bovine adrenal medullae and maintained in primary culture. After prelabeling with 32PO4, exposure of the chromaffin cells to acetylcholine increased the phosphorylation of a Mr approximately equal to 100,000 protein and a Mr approximately equal to 60,000 protein (tyrosine hydroxylase), visualized after separation of total cellular proteins in naDodSO4/polyacrylamide gels. Immunoprecipitation with antibodies to three known phosphoproteins (100-kDa, 87-kDa, and protein III) revealed an acetylcholine-dependent phosphorylation of these proteins. These three proteins were also shown to be present in bovine adrenal chromaffin cells by immunolabeling techniques. 100-kDa is a Mr approximately equal to 100,000 protein selectively phosphorylated by calcium/calmodulin-dependent protein kinase III, 87-kDa is a Mr approximately equal to 87,000 protein selectively phosphorylated by protein kinase C, and protein III is a phosphoprotein doublet of Mr approximately equal to 74,000 (IIIa) and Mr approximately equal to 55,000 (IIIb) phosphorylated by cAMP-dependent protein kinase and calcium/calmodulin-dependent protein kinase I. Furthermore, 100-kDa was shown to be identical to the Mr approximately equal to 100,000 protein whose phosphorylation was increased by acetylcholine treatment. The acetylcholine-dependent increase in phosphorylation of tyrosine hydroxylase, 100-kDa, 87-kDa, and protein III required extracellular calcium and was mimicked by nicotine, veratridine, elevated K+, and calcium ionophore A23187, but not by muscarine. In addition, forskolin increased the phosphorylation of tyrosine hydroxylase, 100-kDa, and protein III, but not that of 87-kDa. Phorbol 12,13-dibutyrate increased the phosphorylation of tyrosine hydroxylase, 87-kDa, and protein III, but not that of 100-kDa. The data demonstrate that cholinergic activation of chromaffin cells increases the phosphorylation of several proteins and that several protein kinase systems may be involved in these effects." @default.
• W2087044564 created "2016-06-24" @default.
• W2087044564 creator A5052825834 @default.
• W2087044564 creator A5074849352 @default.
• W2087044564 creator A5081270367 @default.
• W2087044564 date "1988-03-01" @default.
• W2087044564 modified "2023-10-16" @default.
• W2087044564 title "Cholinergic regulation of protein phosphorylation in bovine adrenal chromaffin cells." @default.
• W2087044564 cites W1515213049 @default.
• W2087044564 cites W1517596202 @default.
• W2087044564 cites W1520391214 @default.
• W2087044564 cites W1523448872 @default.
• W2087044564 cites W1533778318 @default.
• W2087044564 cites W1569556111 @default.
• W2087044564 cites W1583656960 @default.
• W2087044564 cites W1602999298 @default.
• W2087044564 cites W1966994391 @default.
• W2087044564 cites W1976645110 @default.
• W2087044564 cites W1984002543 @default.
• W2087044564 cites W1992170822 @default.
• W2087044564 cites W1993819160 @default.
• W2087044564 cites W2003133471 @default.
• W2087044564 cites W2010553364 @default.
• W2087044564 cites W2018289835 @default.
• W2087044564 cites W2031423487 @default.
• W2087044564 cites W2032862924 @default.
• W2087044564 cites W2042251760 @default.
• W2087044564 cites W2066862811 @default.
• W2087044564 cites W2080871752 @default.
• W2087044564 cites W2093349551 @default.
• W2087044564 cites W2100837269 @default.
• W2087044564 cites W2111817213 @default.
• W2087044564 cites W2163022163 @default.
• W2087044564 cites W2164358316 @default.
• W2087044564 cites W2171250612 @default.
• W2087044564 cites W2171669937 @default.
• W2087044564 cites W254452930 @default.
• W2087044564 doi "https://doi.org/10.1073/pnas.85.5.1677" @default.
• W2087044564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/279837" @default.
• W2087044564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2894032" @default.
• W2087044564 hasPublicationYear "1988" @default.
• W2087044564 type Work @default.
• W2087044564 sameAs 2087044564 @default.
• W2087044564 citedByCount "39" @default.
• W2087044564 countsByYear W20870445642012 @default.
• W2087044564 crossrefType "journal-article" @default.
• W2087044564 hasAuthorship W2087044564A5052825834 @default.
• W2087044564 hasAuthorship W2087044564A5074849352 @default.
• W2087044564 hasAuthorship W2087044564A5081270367 @default.
• W2087044564 hasBestOaLocation W20870445642 @default.
• W2087044564 hasConcept C11960822 @default.
• W2087044564 hasConcept C134018914 @default.
• W2087044564 hasConcept C153911025 @default.
• W2087044564 hasConcept C170493617 @default.
• W2087044564 hasConcept C185592680 @default.
• W2087044564 hasConcept C195794163 @default.
• W2087044564 hasConcept C2775894120 @default.
• W2087044564 hasConcept C2777553839 @default.
• W2087044564 hasConcept C2777597313 @default.
• W2087044564 hasConcept C2779276759 @default.
• W2087044564 hasConcept C2780910648 @default.
• W2087044564 hasConcept C55493867 @default.
• W2087044564 hasConcept C86803240 @default.
• W2087044564 hasConcept C87325107 @default.
• W2087044564 hasConcept C97029542 @default.
• W2087044564 hasConceptScore W2087044564C11960822 @default.
• W2087044564 hasConceptScore W2087044564C134018914 @default.
• W2087044564 hasConceptScore W2087044564C153911025 @default.
• W2087044564 hasConceptScore W2087044564C170493617 @default.
• W2087044564 hasConceptScore W2087044564C185592680 @default.
• W2087044564 hasConceptScore W2087044564C195794163 @default.
• W2087044564 hasConceptScore W2087044564C2775894120 @default.
• W2087044564 hasConceptScore W2087044564C2777553839 @default.
• W2087044564 hasConceptScore W2087044564C2777597313 @default.
• W2087044564 hasConceptScore W2087044564C2779276759 @default.
• W2087044564 hasConceptScore W2087044564C2780910648 @default.
• W2087044564 hasConceptScore W2087044564C55493867 @default.
• W2087044564 hasConceptScore W2087044564C86803240 @default.
• W2087044564 hasConceptScore W2087044564C87325107 @default.
• W2087044564 hasConceptScore W2087044564C97029542 @default.
• W2087044564 hasIssue "5" @default.
• W2087044564 hasLocation W20870445641 @default.
• W2087044564 hasLocation W20870445642 @default.
• W2087044564 hasLocation W20870445643 @default.
• W2087044564 hasLocation W20870445644 @default.
• W2087044564 hasOpenAccess W2087044564 @default.
• W2087044564 hasPrimaryLocation W20870445641 @default.
• W2087044564 hasRelatedWork W1526866619 @default.
• W2087044564 hasRelatedWork W2025409136 @default.
• W2087044564 hasRelatedWork W2057519025 @default.
• W2087044564 hasRelatedWork W2068305192 @default.
• W2087044564 hasRelatedWork W2073946342 @default.
• W2087044564 hasRelatedWork W2075000266 @default.
• W2087044564 hasRelatedWork W2087945599 @default.
• W2087044564 hasRelatedWork W2410202282 @default.
• W2087044564 hasRelatedWork W270452629 @default.
• W2087044564 hasRelatedWork W4243364137 @default.
• W2087044564 hasVolume "85" @default.

• next