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• W2087054927 endingPage "2796" @default.
• W2087054927 startingPage "2786" @default.
• W2087054927 abstract "We investigated the protein profiles of variously aged rat astrocytes in response to oxidative stress. After H2O2-exposure of cells at 100 µM for 30 min, the relative intensity of ten protein spots changed on two-dimensional (2-D) gels compared with control gels after silver staining. Matrix-assisted laser desorption/ionization-time of flight-mass spectrometry (MALDI-TOF-MS) analysis after in-gel digestion revealed that six of these spots corresponded to three kinds of proteins, each of which was composed of a protein and its modified form with a different isoelectric point (pI). These three proteins were identified as peroxiredoxins (PRDXs) II and III, and calpactin I light chain (p11). H2O2-exposure increased the intensity of the spot with lower pI and simultaneously decreased that of the spot with higher pI for both PRDXs II and III. In addition, the expression of annexin VII, S-adenosyl-L-homocysteine hydrolase, elongation factor II fragment (EF-II), and adenosine deaminase was increased by H2O2-exposure in astrocytes from variously aged rats. Using the Pro-Q® Diamond staining, heat shock protein 60 kDa (Hsp 60) and α-tubulin were observed to be phosphorylated upon H2O2-exposure. While phosphorylation of α-tubulin was correlated positively with age, the changes in abundance of ten protein spots as described above were independent of age. These results suggest that aging does not suppress the responses aimed at limiting injury and promoting repair brought about by severe oxidative stress, and might affect cell dynamics including the formation of microtubules." @default.
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• W2087054927 date "2005-07-01" @default.
• W2087054927 modified "2023-10-03" @default.
• W2087054927 title "Age-dependent variations of cell response to oxidative stress: Proteomic approach to protein expression and phosphorylation" @default.
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• W2087054927 doi "https://doi.org/10.1002/elps.200500172" @default.
• W2087054927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15966013" @default.
• W2087054927 hasPublicationYear "2005" @default.
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