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• W2087095797 startingPage "167" @default.
• W2087095797 abstract "In mitotic cells, telomerase adds repeats of a DNA sequence (TTAGGG) to the ends of chromosomes (telomeres) thereby maintaining their length and preventing cellular senescence. We recently reported that the catalytic subunit of telomerase (TERT) is expressed in neuronal progenitor cells and in early postmitotic neurons in the developing rodent brain. We now report that TERT can protect cultured PC12 cells and embryonic hippocampal neurons against death induced by DNA damage. Overexpression of TERT in PC12 cells increases their resistance to the topoisomerase inhibitors camptothecin and etoposide. Hippocampal neurons in which TERT levels are decreased using antisense technology exhibit increased vulnerability to the DNA-damaging agents. Emerging findings suggest that DNA damage may trigger the death of neurons during brain development and in neurodegenerative disorders. Our data therefore suggest roles for TERT in modulating such cell deaths." @default.
• W2087095797 created "2016-06-24" @default.
• W2087095797 creator A5024369563 @default.
• W2087095797 creator A5080235402 @default.
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• W2087095797 date "2001-11-01" @default.
• W2087095797 modified "2023-10-13" @default.
• W2087095797 title "Telomerase protects developing neurons against DNA damage-induced cell death" @default.
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• W2087095797 doi "https://doi.org/10.1016/s0165-3806(01)00237-1" @default.
• W2087095797 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11718848" @default.
• W2087095797 hasPublicationYear "2001" @default.
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