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• W2087101178 abstract "Objective. To study the effects of a novel A-type retrovirus, detected in cocultures of lip biopsy specimens from Sjögren's syndrome (SS) patients and a human T cell line, on the infected T cells. Methods. Interleukin-2 (IL-2) and IL-6 secretion were measured by bioassay and enzyme-linked immunosorbent assay, respectively, in the infected and noninfected cell lines. Surface antigen expression was determined by flow cytometry, using monoclonal antibodies. Protein kinase C (PKC) activity was measured using an enzyme assay kit, and calcium mobilization was assessed with a fluorescent probe. Results. Infected cells expressed less CD4 and IL-6 receptor, but more HLA-DR, compared with noninfected cells. Infected cells also produced less IL-2 and displayed reduced PKC activation and calcium mobilization. A similar defect in calcium mobilization was detected in T cells from SS patients. Conclusion. These data suggest a possible involvement of the newly described retrovirus in T cell abnormalities." @default.
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• W2087101178 date "1992-09-01" @default.
• W2087101178 modified "2023-09-23" @default.
• W2087101178 title "Signal transduction in Sjögren's syndrome T cells. Abnormalities associated with a newly described human A-type retrovirus" @default.
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• W2087101178 doi "https://doi.org/10.1002/art.1780350912" @default.
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