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• W2087103687 abstract "Significance Our study reveals lineage-specific mechanisms of ROS control and associated sensitivity to oxidative DNA damage in the basal and luminal progenitor-enriched subsets of normal human mammary cells. We show that the primitive luminal cells contain more mitochondria, show greater uptake of O 2 , sustain and withstand higher levels of ROS, and have mechanisms that allow them to accrue mutagenic levels of oxidative DNA damage. These findings support a growing body of data suggesting the involvement of primitive luminal cells in the generation of human breast cancers." @default.
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• W2087103687 date "2014-05-12" @default.
• W2087103687 modified "2023-10-01" @default.
• W2087103687 title "Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets" @default.
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• W2087103687 doi "https://doi.org/10.1073/pnas.1403813111" @default.
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