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• W2087110045 endingPage "1427" @default.
• W2087110045 startingPage "1418" @default.
• W2087110045 abstract "Abstract Aggressiveness is highly heritable. Recent experimental work has linked individual differences in a functional polymorphism of the monoamine oxidase-A gene (MAOA) to anger-driven aggression. Other work has implicated the dorsal ACC (dACC) in cognitive-emotional control and the amygdala in emotional arousal. The present imaging genetics study investigated dACC and amygdala reactivity to induced anger control as a function of MAOA genotype. A research assistant asked 38 healthy male undergraduates to control their anger in response to an insult by a rude experimenter. Men with the low-expression allele showed increased dACC and amygdala activation after the insult, but men with the high-expression allele did not. Both dACC and amygdala activation independently mediated the relationship between MAOA genotype and self-reported anger control. Moreover, following the insult, men with the high-functioning allele showed functional decoupling between the amygdala and dACC, but men with the low-functioning allele did not. These results suggest that heightened dACC and amygdala activation and their connectivity are neuroaffective mechanisms underlying anger control in participants with the low-functioning allele of the MAOA gene." @default.
• W2087110045 created "2016-06-24" @default.
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• W2087110045 date "2014-07-01" @default.
• W2087110045 modified "2023-09-27" @default.
• W2087110045 title "A Functional Polymorphism of the <i>MAOA</i> Gene Is Associated with Neural Responses to Induced Anger Control" @default.
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• W2087110045 doi "https://doi.org/10.1162/jocn_a_00592" @default.
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