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• W2087111570 abstract "Adult rat sensory neurones were maintained in short-term tissue culture and their response to histamine was studied by monitoring changes in intracellular [Ca2+] with Fura-2. The proportion of histamine-sensitive neurones increased as the concentration increased from 10 μM to 10 mM. The fraction of responding cells did not change significantly over the first week in culture. About 60% of histamine-sensitive cells were insensitive to capsaicin and these cells tended to be of small diameter. The integrated calcium response to histamine was greatest at 100 μM when the response consisted of two phases: an initial short-lasting transient followed by a sustained plateau that was dependent on extracellular calcium. This response was blocked by the histamine H1 receptor antagonist mepyramine but not by cimetidine or thioperamide which block H2 and H3 receptors, respectively. Moreover, application of histamine increased the intracellular concentration of inositol 1,4,5-trisphosphate – an effect blocked by mepyramine. These data show that the response is mediated by H1 receptors. The phospholipase C inhibitor U73122 blocked the response to 100 μM histamine and significantly reduced the fraction of cells responding to 1 mM and 10 mM histamine as did removal of extracellular calcium. A combination of U73122 and calcium-free medium abolished all responses to histamine. These data suggest that in addition to activating phospholipase C, high concentrations of histamine gate an influx of calcium that is independent of store depletion. The implications of these results for the transduction of pruritic stimuli is discussed." @default.
• W2087111570 created "2016-06-24" @default.
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• W2087111570 date "2002-03-01" @default.
• W2087111570 modified "2023-10-05" @default.
• W2087111570 title "Characterisation of the calcium responses to histamine in capsaicin-sensitive and capsaicin-insensitive sensory neurones" @default.
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• W2087111570 doi "https://doi.org/10.1016/s0306-4522(01)00561-9" @default.
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