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• W2087120643 abstract "Electroencephalographic measures combined with cognitive tasks are widely used for the assessment of cognitive and pathophysiological changes in Alzheimer's disease (AD). Instead of the analysis of EEG data obtained during the performance of the task, in this study data recorded in the immediate after-task period were analyzed. It was expected that this period would correspond to the electrophysiological consequences of the cognitive effort. Data of 14 patients with AD (MMS score: 16–24) were compared to that of 10 healthy control subjects. Reverse counting of a fix duration was used as a cognitive task. Changes of relative frequency spectra, and those of inter-and intrahemispheric coherence were analyzed. Relative theta power was significantly higher in AD patients compared to the controls both before and after the task. The performance of the task resulted in an increase of the relative alpha2 band in the AD group, whereas it slightly decreased in the control group. The most prominent coherence differences between AD and controls were found in the alpha1 band, especially for long-range coherence values. Coherence in this frequency band increased in the control group following the task, not seen in the AD group. We conclude that EEG parameters calculated from epochs following the completion of a cognitive task clearly differentiates patients with AD from normal controls. The electrophysiological changes found in AD may correspond to the decrease of functional connectivity of cortical areas and to the malfunctioning of the networks engaged in the cognitive task investigated." @default.
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• W2087120643 date "2007-09-01" @default.
• W2087120643 modified "2023-10-17" @default.
• W2087120643 title "Changes of EEG spectra and coherence following performance in a cognitive task in Alzheimer's disease" @default.
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• W2087120643 doi "https://doi.org/10.1016/j.ijpsycho.2007.05.002" @default.
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