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• W2087121423 abstract "DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1-/- embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions." @default.
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• W2087121423 date "2005-01-19" @default.
• W2087121423 modified "2023-09-25" @default.
• W2087121423 title "DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development" @default.
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• W2087121423 doi "https://doi.org/10.1016/j.febslet.2004.12.090" @default.
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