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• W2087129430 endingPage "267" @default.
• W2087129430 startingPage "258" @default.
• W2087129430 abstract "Phylostratigraphy is a method for dating the evolutionary emergence of a gene or gene family by identifying its homologs across the tree of life, typically by using BLAST searches. Applying this method to all genes in a species, or genomic phylostratigraphy, allows investigation of genome-wide patterns in new gene origination at different evolutionary times and thus has been extensively used. However, gene age estimation depends on the challenging task of detecting distant homologs via sequence similarity, which is expected to have differential accuracies for different genes. Here, we evaluate the accuracy of phylostratigraphy by realistic computer simulation with parameters estimated from genomic data, and investigate the impact of its error on findings of genome evolution. We show that 1) phylostratigraphy substantially underestimates gene age for a considerable fraction of genes, 2) the error is especially serious when the protein evolves rapidly, is short, and/or its most conserved block of sites is small, and 3) these errors create spurious nonuniform distributions of various gene properties among age groups, many of which cannot be predicted a priori. Given the high likelihood that conclusions about gene age are faulty, we advocate the use of realistic simulation to determine if observations from phylostratigraphy are explainable, at least qualitatively, by a null model of biased measurement, and in all cases, critical evaluation of results." @default.
• W2087129430 created "2016-06-24" @default.
• W2087129430 creator A5082143549 @default.
• W2087129430 creator A5084753943 @default.
• W2087129430 date "2014-10-13" @default.
• W2087129430 modified "2023-10-07" @default.
• W2087129430 title "Phylostratigraphic Bias Creates Spurious Patterns of Genome Evolution" @default.
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• W2087129430 doi "https://doi.org/10.1093/molbev/msu286" @default.
• W2087129430 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6312082" @default.
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• W2087129430 hasPublicationYear "2014" @default.
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