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- W2087135061 abstract "Alcoholic abuse is of great interest in forensic medicine, for the evaluation of driving and working ability, for permanent invalidity to alcohol-related pathologies and for the high incidence of alcohol-related deaths. It is a quantitative disorder, with a combined incidence of environmental and genetic factors. Since it was observed that variations in ADH4 gene are associated with alcoholism, SNPs mapping in different regions of ADH4 gene were selected. A new approach was applied in this study: mutations that could modify the splicing sites were selected using “Splice site prediction” available at http://www.fruitfly.orgseq_tools/sp/lice.html; in addition, since the correct splicing is finely regulated by RNA binding proteins, SNPs that could affect splicing, destroying or creating protein target sequences and changing RNA secondary structure, were predicted by a tool available at www.introni.it.206 unrelated volunteers, diagnosed for alcohol dependence (DSM-IV), were included in this study. SNPs typing was performed setting up 2 multiplex PCRs and minisequencing reactions.12 SNPs were selected from literature data and 26 SNPs, among 233 polymorphisms screened, were chosen by computational analyses." @default.
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- W2087135061 date "2008-08-01" @default.
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- W2087135061 title "Association of genetic variations in alcohol dehydrogenase 4 with alcohol dependence in Italian population sample" @default.
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- W2087135061 doi "https://doi.org/10.1016/j.fsigss.2007.10.127" @default.
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